Evidence map›Paper›PMID 25386054›Full record

ReviewWorld journal of gastroenterology2014

Primary prevention of colorectal cancer: myth or reality?

Marcela Crosara Teixeira, Maria Ignez Braghiroli, Jorge Sabbaga, Paulo M Hoff

Open access · bronzeAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Prevention of Colorectal Neoplasia.Clinics in colon and rectal surgery · 2016
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Mouse models of colorectal cancer as preclinical models.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015
    Review
  17. Molecular aspects of intestinal calcium absorption.World journal of gastroenterology · 2015
    Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marcela Crosara TeixeiraMarcela Crosara Teixeira, Maria Ignez Braghiroli, Jorge Sabbaga, Paulo M Hoff, Division of Medical Oncology, Instituto do Câncer do Estado de São Paulo, Hospital Sírio Libanês, São Paulo, SP CEP 01246-000, Brazil.
Maria Ignez BraghiroliMarcela Crosara Teixeira, Maria Ignez Braghiroli, Jorge Sabbaga, Paulo M Hoff, Division of Medical Oncology, Instituto do Câncer do Estado de São Paulo, Hospital Sírio Libanês, São Paulo, SP CEP 01246-000, Brazil.
Jorge SabbagaMarcela Crosara Teixeira, Maria Ignez Braghiroli, Jorge Sabbaga, Paulo M Hoff, Division of Medical Oncology, Instituto do Câncer do Estado de São Paulo, Hospital Sírio Libanês, São Paulo, SP CEP 01246-000, Brazil.
Paulo M HoffMarcela Crosara Teixeira, Maria Ignez Braghiroli, Jorge Sabbaga, Paulo M Hoff, Division of Medical Oncology, Instituto do Câncer do Estado de São Paulo, Hospital Sírio Libanês, São Paulo, SP CEP 01246-000, Brazil.
Instituto do Câncer do Estado de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer incidence has been rising strongly in parallel with economic development. In the past few decades, much has been learned about the lifestyle, dietary and medication risk factors for this malignancy. With respect to lifestyle, compelling evidence indicates that prevention of weight gain and maintenance of a reasonable level of physical activity can positively influence in lowering the risk. Although there is controversy about the role of specific nutritional factors, consideration of dietary pattern as a whole appears useful for formulating recommendations. Though quite often recommended, the role for many supplements, including omega-3, vitamin D, folate, and vitamin B6, remains unsettled. Only calcium and vitamin D supplementation appear to add a modest benefit, particularly in those with a low daily intake. With regard to chemoprevention, medications such as aspirin and nonsteroidal anti-inflammatory drugs, and postmenopausal hormonal replacement for women might be associated with substantial reductions in colorectal cancer risk, though their utility is affected by their side effect profile. However, the role of agents such as statins, bisphosphonates and antioxidants have yet to be determined. Ultimately, primary prevention strategies focusing on modifying environmental, lifestyle risk factors, and chemopreventive drugs are options that have already been tested, and may impact on colon cancer incidence.

Indexed as

DietExerciseRisk Reduction BehaviorAnticarcinogenic AgentsColorectal NeoplasmsDietary SupplementsFemaleHumansIncidenceLife StyleMaleNutritional StatusPrimary PreventionRecommended Dietary AllowancesRisk AssessmentRisk FactorsAnticarcinogenic AgentsChemopreventionColorectal cancerDietPhysical activityPrimary prevention

Identifiers

PMID25386054
PMCPMC4223239
OpenAlexW1611653419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.