SynthesisEuropean journal of epidemiology2015
Targeted hepatitis C antibody testing interventions: a systematic review and meta-analysis.
Synthesis in European journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Interventions to Improve Uptake of Direct-Acting Antivirals for Hepatitis C Virus in Priority Populations: A Systematic Review.Frontiers in public health · 2022Pooled it
- Hepatitis B and C testing strategies in healthcare and community settings in the EU/EEA: A systematic review.Journal of viral hepatitis · 2019Pooled it
- A systematic review and meta-analysis of community and primary-care-based hepatitis C testing and treatment services that employ direct acting antiviral drug treatments.BMC health services research · 2019Pooled it
- Diagnostic accuracy of tests to detect Hepatitis C antibody: a meta-analysis and review of the literature.BMC infectious diseases · 2017Pooled it
- Trial
- Community Versus Facility-Based Services to Improve the Screening of Active Hepatitis C Virus Infection in Cambodia: The ANRS 12384 CAM-C Cluster Randomized Controlled Trial-Protocol for a Mixed Methods Study.JMIR research protocols · 2024Article
- Liver function tests in primary care provide a key opportunity to diagnose and engage patients with hepatitis C.Epidemiology and infection · 2022Article
- On-site testing and case management to improve hepatitis C care in drug users: a prospective, longitudinal, multicenter study in the DAA era.BMC public health · 2021Article
- Untreated alcohol use disorder in people who inject drugs (PWID) in France: a major barrier to HCV treatment uptake (the ANRS-FANTASIO study).Addiction (Abingdon, England) · 2020Article
- Doubling Hepatitis C Virus Screening in Primary Care Using Advanced Electronic Health Record Tools-A Non-Randomized Controlled Trial.Journal of general internal medicine · 2020Article
- HepCare Europe: a new user-friendly hepatitis C care service model. What have we learned? What are the remaining challenges?The Journal of antimicrobial chemotherapy · 2019Article
- Missed opportunities for diagnosing viral hepatitis C in Poland. Results from routine HCV testing at the Emergency Department in the Hospital for Infectious Diseases in Warsaw.Clinical and experimental hepatology · 2019Article
- Streamlining the screening cascade for active Hepatitis C in Russia: A cost-effectiveness analysis.PloS one · 2019Article
- Detecting Hepatitis B and C by Combined Public Health and Primary Care Birth Cohort Testing.Annals of family medicine · 2018Article
- A quasi-experimental evaluation of dried blood spot testing through community pharmacies in the Tayside region of Scotland.Frontline gastroenterology · 2017Article
- Uptake of hepatitis C screening, characteristics of patients tested, and intervention costs in the BEST-C study.Hepatology (Baltimore, Md.) · 2017Article
- Article
- The HCV care continuum among people who use drugs: protocol for a systematic review and meta-analysis.Systematic reviews · 2016Article
- Conceptualizing Care Continua: Lessons from HIV, Hepatitis C Virus, Tuberculosis and Implications for the Development of Improved Care and Prevention Continua.Frontiers in public health · 2016Review
- Urgent action to fight hepatitis C in people who inject drugs in Europe.Hepatology, medicine and policy · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Testing for hepatitis C virus (HCV) infection may reduce the risk of liver-related morbidity, by facilitating earlier access to treatment and care. This review investigated the effectiveness of targeted testing interventions on HCV case detection, treatment uptake, and prevention of liver-related morbidity. A literature search identified studies published up to 2013 that compared a targeted HCV testing intervention (targeting individuals or groups at increased risk of HCV) with no targeted intervention, and results were synthesised using meta-analysis. Exposure to a targeted testing intervention, compared to no targeted intervention, was associated with increased cases detected [number of studies (n) = 14; pooled relative risk (RR) 1.7, 95% CI 1.3, 2.2] and patients commencing therapy (n = 4; RR 3.3, 95% CI 1.1, 10.0). Practitioner-based interventions increased test uptake and cases detected (n = 12; RR 3.5, 95% CI 2.5, 4.8; and n = 10; RR 2.2, 95% CI 1.4, 3.5, respectively), whereas media/information-based interventions were less effective (n = 4; RR 1.5, 95% CI 0.7, 3.0; and n = 4; RR 1.3, 95% CI 1.0, 1.6, respectively). This meta-analysis provides for the first time a quantitative assessment of targeted HCV testing interventions, demonstrating that these strategies were effective in diagnosing cases and increasing treatment uptake. Strategies involving practitioner-based interventions yielded the most favourable outcomes. It is recommended that testing should be targeted at and offered to individuals who are part of a population with high HCV prevalence, or who have a history of HCV risk behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.