ArticleObesity (Silver Spring, Md.)2015
Exposure to prenatal smoking and early-life body composition: the healthy start study.
Article in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Accelerated epigenetic age at birth and child emotional and behavioura development in early childhood: a meta-analysis of four prospective cohort studies in ECHO.Epigenetics · 2023Pooled it
- The association between active tobacco use during pregnancy and growth outcomes of children under five years of age: a systematic review and meta-analysis.BMC public health · 2018Pooled it
- Maternal Diet Quality Is Associated with Placental Proteins in the Placental Insulin/Growth Factor, Environmental Stress, Inflammation, and mTOR Signaling Pathways: The Healthy Start ECHO Cohort.The Journal of nutrition · 2022Trial
- Greater Neonatal Fat-Free Mass and Similar Fat Mass Following a Randomized Trial to Control Excess Gestational Weight Gain.Obesity (Silver Spring, Md.) · 2018Trial
- Placental insulin-mTOR and stress-inflammatory signaling patterns are associated with childhood adiposity.BMC medicine · 2026Article
- Evaluating statistical methods to predict indoor black carbon in an urban birth cohort.Indoor environments · 2025Article
- Maternal Serum Metabolomics in Mid-Pregnancy Identifies Lipid Pathways as a Key Link to Offspring Obesity in Early Childhood.International journal of molecular sciences · 2024Article
- Prenatal tobacco and cannabis co-exposure and offspring obesity development from birth to mid-childhood.Pediatric obesity · 2023Article
- Application of Life's Essential 8 to assess cardiovascular health during early childhood.Annals of epidemiology · 2023Article
- Prenatal exposure to tobacco and adverse birth outcomes: effect modification by folate intake during pregnancy.Maternal health, neonatology and perinatology · 2022Article
- Pre- and Perinatal Correlates of Ideal Cardiovascular Health during Early Childhood: A Prospective Analysis in the Healthy Start Study.The Journal of pediatrics · 2021Article
- Joint effects of ambient air pollution and maternal smoking on neonatal adiposity and childhood BMI trajectories in the Healthy Start study.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Neonatal body composition: crossectional study in healthy term singletons in Germany.BMC pediatrics · 2019Article
- Fetal exposure to maternal active and secondhand smoking with offspring early-life growth in the Healthy Start study.International journal of obesity (2005) · 2019Article
- Air displacement plethysmography (pea pod) in full-term and pre-term infants: a comprehensive review of accuracy, reproducibility, and practical challenges.Maternal health, neonatology and perinatology · 2018Review
- An observational cohort study of weight- and length-derived anthropometric indicators with body composition at birth and 5 mo: the Healthy Start study.The American journal of clinical nutrition · 2017Observational
- Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study.Nutrients · 2017Article
- Tobacco Exposure and Conditional Weight-for-Length Gain by 2 Years of Age.Journal of pediatric psychology · 2017Article
- Maternal smoking during pregnancy and rapid weight gain from birth to early infancy.Journal of epidemiology · 2017Article
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo examine associations between exposure to prenatal smoking and early-life changes in fat mass (FM), fat-free mass (FFM), and anthropometrics.
methodsAbout 670 mother-offspring pairs were analyzed in the longitudinal Healthy Start study. Maternal smoking data were collected during prenatal research visits. Offspring body composition and size were measured by air displacement plethysmography at delivery and postnatal follow-up (5 months) visits.
resultsComparing exposed and unexposed offspring, exposure to prenatal smoking was significantly associated with reduced neonatal FM (P = 0.007) and FFM (P = 0.02). In contrast, at 5 months, exposed offspring had comparable FM (P = 0.61) and FFM (P = 0.41). After subsequent adjustment for birth weight, offspring exposed to prenatal smoking had significantly greater FFM (154.7 g, 0.5, 309.0; P = 0.049) and sum of skinfolds (2.7 mm, 0.06, 5.3; P = 0.04). From delivery to follow-up, exposed offspring had significantly greater increases in FFM (156.4 g, 2.8, 310.1; P = 0.046) and sum of skinfolds (2.7 mm, 0.06, 5.3; P = 0.04), even after adjustment for respective delivery measures.
conclusionsExposure to prenatal smoking was significantly associated with rapid postnatal growth, which may increase the offspring's risk of metabolic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.