ArticleProceedings of the National Academy of Sciences of the United States of America2014
Nonsensory target-dependent organization of piriform cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 81 citations in OpenAlex.
- The Wire Is Not the Territory: Understanding Representational Drift in Olfaction With Dynamical Systems Theory.Topics in cognitive science · 2026Article
- Perception and neural representation of intermittent odor stimuli in mice.Nature communications · 2026Article
- Article
- A topographical organization in the primary olfactory cortex.Nature communications · 2026Article
- Spatial segregation of piriform output neurons toward cognitive and emotional networks.PNAS nexus · 2026Article
- How do we think and what is the neural circuit mechanism for it? Possible roles of working memory and inner speech in thinking.Frontiers in human neuroscience · 2026Article
- Projection-specific Routing of Odor Information in the Olfactory Cortex.bioRxiv : the preprint server for biology · 2025Article
- Wider Than the Sky: An Alternative to "Mapping" the World Onto the Brain.The European journal of neuroscience · 2025Article
- Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top-Down Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal identity and reward contingency signals during rule-reversal.Nature communications · 2025Article
- The Orbitofrontal Cortex Is Required for Learned Modulation of Innate Olfactory Behavior.eNeuro · 2024Article
- Odors in space.Frontiers in neural circuits · 2024Review
- One respiratory cycle as a minimum time unit for making behavioral decisions in the mammalian olfactory system.Frontiers in neuroscience · 2024Article
- Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal reward contingency signals during rule-reversal.bioRxiv : the preprint server for biology · 2023Article
- Role of Piriform Cortex and Its Afferent Projections in Relapse to Fentanyl Seeking after Food Choice-Induced Voluntary Abstinence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Retrieval of olfactory fear memory alters cell proliferation and expression of pCREB and pMAPK in the corticomedial amygdala and piriform cortex.Chemical senses · 2022Article
- Human hippocampal connectivity is stronger in olfaction than other sensory systems.Progress in neurobiology · 2021Article
- Specific contribution of neurons from the Dbx1 lineage to the piriform cortex.Scientific reports · 2021Article
- An Evolutionary Microcircuit Approach to the Neural Basis of High Dimensional Sensory Processing in Olfaction.Frontiers in cellular neuroscience · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The piriform cortex (PCX) is the largest component of the olfactory cortex and is hypothesized to be the locus of odor object formation. The distributed odorant representation found in PCX contrasts sharply with the topographical representation seen in other primary sensory cortices, making it difficult to test this view. Recent work in PCX has focused on functional characteristics of these distributed afferent and association fiber systems. However, information regarding the efferent projections of PCX and how those may be involved in odor representation and object recognition has been largely ignored. To investigate this aspect of PCX, we have used the efferent pathway from mouse PCX to the orbitofrontal cortex (OFC). Using double fluorescent retrograde tracing, we identified the output neurons (OPNs) of the PCX that project to two subdivisions of the OFC, the agranular insula and the lateral orbitofrontal cortex (AI-OPNs and LO-OPNs, respectively). We found that both AI-OPNs and LO-OPNs showed a distinct spatial topography within the PCX and fewer than 10% projected to both the AI and the LO as judged by double-labeling. These data revealed that the efferent component of the PCX may be topographically organized. Further, these data suggest a model for functional organization of the PCX in which the OPNs are grouped into parallel output circuits that provide olfactory information to different higher centers. The distributed afferent input from the olfactory bulb and the local PCX association circuits would then ensure a complete olfactory representation, pattern recognition capability, and neuroplasticity in each efferent circuit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.