ArticleJournal of proteome research2014
Following the digestion of milk proteins from mother to baby.
Article in Journal of proteome research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Comparison of the acute metabolic effect of different infant formulas and human milk in healthy adults: a randomized trial.Nutrition & diabetes · 2021Trial
- Article
- Relevance of Milk Composition to Human Longitudinal Growth from Infancy Through Puberty: Facts and Controversies.Nutrients · 2025Review
- Breast milk-saliva interactions in shaping early mucosal immunity.Frontiers in immunology · 2025Review
- Milk: A Scientific Model for Diet and Health Research in the 21st Century.Frontiers in nutrition · 2022Review
- Article
- [Effect of sample preparation on analysis of human milk endogenous peptides using liquid chromatography-tandem mass spectrometry].Se pu = Chinese journal of chromatography · 2021Article
- Review
- Bioactive Compounds in Infant Formula and Their Effects on Infant Nutrition and Health: A Systematic Literature Review.International journal of food science · 2021Review
- Human milk and infant formulae: Peptide differences and the opportunity to address the functional gap.Current research in food science · 2020Article
- Quantitative Analysis of Antibody Survival across the Infant Digestive Tract Using Mass Spectrometry with Parallel Reaction Monitoring.Foods (Basel, Switzerland) · 2020Article
- Degradation of Proteins From Colostrum and Mature Milk From Chinese Mothers Using anFrontiers in nutrition · 2020Article
- The Functional Power of the Human Milk Proteome.Nutrients · 2019Review
- Peptidomic profiling of human milk with LC-MS/MS reveals pH-specific proteolysis of milk proteins.Food chemistry · 2019Article
- Premature Infants have Lower Gastric Digestion Capacity for Human Milk Proteins than Term Infants.Journal of pediatric gastroenterology and nutrition · 2018Article
- Changes in Proteases, Antiproteases, and Bioactive Proteins From Mother's Breast Milk to the Premature Infant Stomach.Journal of pediatric gastroenterology and nutrition · 2018Article
- Release of functional peptides from mother's milk and fortifier proteins in the premature infant stomach.PloS one · 2018Article
- Protein Digestion of Baby Foods: Study Approaches and Implications for Infant Health.Molecular nutrition & food research · 2018Review
- Analysis of Milk from Mothers Who Delivered Prematurely Reveals Few Changes in Proteases and Protease Inhibitors across Gestational Age at Birth and Infant Postnatal Age.The Journal of nutrition · 2017Article
- Enzymes in Human Milk.Nestle Nutrition Institute workshop series · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Little is known about the digestive process in infants. In particular, the chronological activity of enzymes across the course of digestion in the infant remains largely unknown. To create a temporal picture of how milk proteins are digested, enzyme activity was compared between intact human milk samples from three mothers and the gastric samples from each of their 4-12 day postpartum infants, 2 h after breast milk ingestion. The activities of 7 distinct enzymes are predicted in the infant stomach based on their observed cleavage pattern in peptidomics data. We found that the same patterns of cleavage were evident in both intact human milk and gastric milk samples, demonstrating that the enzyme activities that begin in milk persist in the infant stomach. However, the extent of enzyme activity is found to vary greatly between the intact milk and gastric samples. Overall, we observe that milk-specific proteins are cleaved at higher levels in the stomach compared to human milk. Notably, the enzymes we predict here only explain 78% of the cleavages uniquely observed in the gastric samples, highlighting that further investigation of the specific enzyme activities associated with digestion in infants is warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.