ArticleAntimicrobial agents and chemotherapy2015
Trends in serotype distribution and antimicrobial susceptibility in Salmonella enterica isolates from humans in Belgium, 2009 to 2013.
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Development of an Acid-Protective Polymer Encapsulation Formulation for Oral Delivery of Salmonella Phages.Viruses · 2025Article
- Assessing antimicrobial resistance profiles ofJournal of medical microbiology · 2024Article
- Anti-Antibiotics (Basel, Switzerland) · 2023Article
- Article
- The temporal dynamics of antimicrobial-resistantNational science review · 2023Article
- Monitoring of Antimicrobial Resistance ofPathogens (Basel, Switzerland) · 2023Article
- Phenotypic and genotypic antimicrobial resistance correlation and plasmid characterization inFrontiers in public health · 2023Article
- Aptamer-Based Electrochemical Biosensors for the Detection ofDiagnostics (Basel, Switzerland) · 2022Article
- Antimicrobial Resistance ofAnimals : an open access journal from MDPI · 2021Article
- Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases ofAntibiotics (Basel, Switzerland) · 2021Review
- Genotypic Diversity of Ciprofloxacin Nonsusceptibility and Its Relationship with Minimum Inhibitory Concentrations in NontyphoidalAntibiotics (Basel, Switzerland) · 2021Article
- Heavy Metal Resistance inFrontiers in microbiology · 2021Article
- Non-TyphoidalAnimals : an open access journal from MDPI · 2020Review
- Investigation of a Salmonellosis Outbreak Caused by Multidrug ResistantFrontiers in microbiology · 2020Article
- Antimicrobial resistance and genetic diversity ofFood science & nutrition · 2019Article
- Prevalence and Characterization of Fluoroquinolone ResistantFrontiers in microbiology · 2019Article
- Transmission of ciprofloxacin resistance inEmerging microbes & infections · 2019Article
- Evolution and transmission of a conjugative plasmid encoding both ciprofloxacin and ceftriaxone resistance in Salmonella.Emerging microbes & infections · 2019Article
- Identification and Characterization of Conjugative Plasmids That Encode Ciprofloxacin Resistance in Salmonella.Antimicrobial agents and chemotherapy · 2018Article
- Increasing Antimicrobial Resistance in Nontyphoidal Salmonella Isolates in Australia from 1979 to 2015.Antimicrobial agents and chemotherapy · 2018Article
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Abstract
The Belgian National Reference Centre for Salmonella received 16,544 human isolates of Salmonella enterica between January 2009 and December 2013. Although 377 different serotypes were identified, the landscape is dominated by S. enterica serovars Typhimurium (55%) and Enteritidis (19%) in a ratio which is inverse to European Union averages. With outbreaks of Salmonella serotypes Ohio, Stanley, and Paratyphi B variant Java as prime examples, 20 serotypes displayed significant fluctuations in this 5-year period. Typhoid strains account for 1.2% of Belgian salmonellosis cases. Large-scale antibiotic susceptibility analyses (n = 4,561; panel of 12 antibiotics) showed declining resistance levels in S. Enteritis and Typhimurium isolates for 8 and 3 tested agents, respectively. Despite low overall resistance to ciprofloxacin (4.4%) and cefotaxime (1.6%), we identified clonal lineages of Salmonella serotypes Kentucky and Infantis displaying rising resistance against these clinically important drugs. Quinolone resistance is mainly mediated by serotype-specific mutations in GyrA residues Ser83 and Asp87 (92.2% not wild type), while an additional ParC_Ser80Ile mutation leads to ciprofloxacin resistance in 95.5% S. Kentucky isolates, which exceeds European averages. Plasmid-mediated quinolone resistance (PMQR) alleles qnrA1 (n = 1), qnrS (n = 9), qnrD1 (n = 4), and qnrB (n = 4) were found in only 3.0% of 533 isolates resistant to nalidixic acid. In cefotaxime-resistant isolates, we identified a broad range of Ambler class A and C β-lactamase genes (e.g., bla(SHV-12), blaTEM-52, bla(CTX-M-14), and bla(CTX-M-15)) commonly associated with members of the family Enterobacteriaceae. In conclusion, resistance to fluoroquinolones and cefotaxime remains rare in human S. enterica, but clonal resistant serotypes arise, and continued (inter)national surveillance is mandatory to understand the origin and routes of dissemination thereof.
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