SynthesisJournal of neurology2015
Prognostic factors for the course of functional status of patients with ALS: a systematic review.
Synthesis in Journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies.Molecular diagnosis & therapy · 2020Pooled it
- Metabolic Alteration and Amyotrophic Lateral Sclerosis Outcome: A Systematic Review.Frontiers in neurology · 2019Pooled it
- Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis.JAMA neurology · 2017Trial
- Impact of Built-In Software Monitoring on Survival in Amyotrophic Lateral Sclerosis Patients Receiving Home Mechanical Ventilation: A Cohort Study.Journal of clinical medicine · 2026Article
- Fasudil attenuates disease spreading in ALS - a post-hoc analysis of the ROCK-ALS trial.medRxiv : the preprint server for health sciences · 2025Article
- Incidence and mortality of ALS: a 42-year population-based nationwide study.Journal of neurology · 2024Article
- Update on recent advances in amyotrophic lateral sclerosis.Journal of neurology · 2024Review
- Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis.Open medicine (Warsaw, Poland) · 2024Article
- Dynamic effects of prognostic factors and individual survival prediction for amyotrophic lateral sclerosis disease.Annals of clinical and translational neurology · 2023Article
- Exploring the association between outcome measures to guide clinical management in patients with amyotrophic lateral sclerosis.Journal of physical therapy science · 2022Article
- Milano-Torino Staging and Long-Term Survival in Chinese Patients with Amyotrophic Lateral Sclerosis.Cells · 2021Article
- The Impact of Lifetime Alcohol and Cigarette Smoking Loads on Amyotrophic Lateral Sclerosis Progression: A Cross-Sectional Study.Life (Basel, Switzerland) · 2021Article
- Coffee and Tea Consumption Impact on Amyotrophic Lateral Sclerosis Progression: A Multicenter Cross-Sectional Study.Frontiers in neurology · 2021Article
- Decreased Mitochondrial Function, Biogenesis, and Degradation in Peripheral Blood Mononuclear Cells from Amyotrophic Lateral Sclerosis Patients as a Potential Tool for Biomarker Research.Molecular neurobiology · 2020Article
- Diaphragmatic CMAP amplitude from phrenic nerve stimulation predicts functional decline in ALS.Journal of neurology · 2020Article
- Spinal Anesthesia for Amyotrophic Lateral Sclerosis Patient Undergoing Lower Extremity Orthopedic Surgery: An Overview of the Anesthetic Considerations.International medical case reports journal · 2020Article
- Poor emotional well-being is associated with rapid progression in amyotrophic lateral sclerosis.eNeurologicalSci · 2019Article
- Amyotrophic lateral sclerosis and anesthesia: a case series and review of the literature.Journal of anesthesia · 2019Review
- Machine Learning in Amyotrophic Lateral Sclerosis: Achievements, Pitfalls, and Future Directions.Frontiers in neuroscience · 2019Review
- Using an onset-anchored Bayesian hierarchical model to improve predictions for amyotrophic lateral sclerosis disease progression.BMC medical research methodology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The progressive course of amyotrophic lateral sclerosis (ALS) results in an ever-changing spectrum of the care needs of patients with ALS. Knowledge of prognostic factors for the functional course of ALS may enhance clinical prediction and improve the timing of appropriate interventions. Our objective was to systematically review the evidence regarding prognostic factors for the rate of functional decline of patients with ALS, assessed with versions of the ALS Functional Rating Scale (ALSFRS). Two reviewers independently assessed the methodological quality of the thirteen included studies using the Quality in Prognosis Studies (QUIPS) tool. The overall quality of evidence for each prognostic factor was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, considering risk of bias, imprecision, inconsistency, indirectness, and publication bias. The quality of evidence for the prognostic value of age at onset, site of onset, time from symptom onset to diagnosis, and ALSFRS-Revised baseline score was low, mainly due to the limited data and inconsistency of results in the small number of studies included. The prognostic value of initial rate of disease progression, age at diagnosis, forced vital capacity, frontotemporal dementia, body mass index, and comorbidity remains unclear. We conclude that the current evidence on prognostic factors for functional decline in ALS is insufficient to allow the development of a prediction tool that can support clinical decisions. Given the limited data, future prognostic studies may need to focus on factors that have a predictive value for a decline in ALSFRS(-R) domain scores, preferably based on internationally collected and shared data.
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