Trial reportJournal of behavioral medicine2015
Neurophysiological evidence for remediation of reward processing deficits in chronic pain and opioid misuse following treatment with Mindfulness-Oriented Recovery Enhancement: exploratory ERP findings from a pilot RCT.
Trial report in Journal of behavioral medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mindfulness-based cognitive therapy for bipolar disorder: A systematic review.Journal of affective disorders · 2018Pooled it
- Mindfulness-Oriented Recovery Enhancement remediates anhedonia in chronic opioid use by enhancing neurophysiological responses during savoring of natural rewards.Psychological medicine · 2023Trial
- A pilot randomized clinical trial of mindfulness-oriented recovery enhancement as an adjunct to methadone treatment for people with opioid use disorder and chronic pain: Impact on illicit drug use, health, and well-being.Journal of substance abuse treatment · 2021Trial
- Performance of healthy persons under pain in different cognitive load tasks: An event-related potential study on experimental pain individuals.Brain and behavior · 2020Trial
- Mindfulness-Oriented Recovery Enhancement reduces opioid craving among individuals with opioid use disorder and chronic pain in medication assisted treatment: Ecological momentary assessments from a stage 1 randomized controlled trial.Drug and alcohol dependence · 2019Trial
- Mindfulness-oriented recovery enhancement reduces opioid misuse risk via analgesic and positive psychological mechanisms: A randomized controlled trial.Journal of consulting and clinical psychology · 2019Trial
- Effects of Mindfulness-Oriented Recovery Enhancement Versus Social Support on Negative Affective Interference During Inhibitory Control Among Opioid-Treated Chronic Pain Patients: A Pilot Mechanistic Study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Trial
- Mindfulness-Oriented Recovery Enhancement versus CBT for co-occurring substance dependence, traumatic stress, and psychiatric disorders: Proximal outcomes from a pragmatic randomized trial.Behaviour research and therapy · 2016Trial
- Mindfulness-Oriented Recovery Enhancement Restructures Reward Processing and Promotes Interoceptive Awareness in Overweight Cancer Survivors: Mechanistic Results From a Stage 1 Randomized Controlled Trial.Integrative cancer therapiesTrial
- Misinterpreting Electrophysiology in Human Cognitive Neuroscience.Psychophysiology · 2026Review
- Positive Emotion Regulation in Addiction: A New Frontier for Recovery Science.Current addiction reports · 2026Review
- The late positive potential predicts contingency management outcomes for cocaine use disorder.Drug and alcohol dependence · 2025Article
- Commentary With Study Protocol: Implementation and Effectiveness of Mindfulness-Oriented Recovery Enhancement (MORE) as an Adjunct to Methadone Treatment for Opioid Use Disorder (IMPOWR-MORE).Substance use & addiction journal · 2025Article
- Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder.Annals of medicine · 2024Article
- Behavioral therapies targeting reward mechanisms in substance use disorders.Pharmacology, biochemistry, and behavior · 2024Review
- Integrating mindfulness into the extended process model of emotion regulation: The dual-mode model of mindful emotion regulation.Emotion (Washington, D.C.) · 2024Review
- Development and feasibility of a mindfulness-based dance/movement therapy intervention for chronic low back pain.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Mindfulness-based neurofeedback: A systematic review of EEG and fMRI studies.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Restructuring reward: A pilot study to enhance natural reward response in adults with cannabis use disorder.Drug and alcohol dependence · 2023Article
- Potential Biological Markers and Treatment Implications for Binge Eating Disorder and Behavioral Addictions.Nutrients · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Dysregulated processing of natural rewards may be a central pathogenic process in the etiology and maintenance of prescription opioid misuse and addiction among chronic pain patients. This study examined whether a Mindfulness-Oriented Recovery Enhancement (MORE) intervention could augment natural reward processing through training in savoring as indicated by event-related brain potentials (ERPs). Participants were chronic pain patients at risk for opioid misuse who were randomized to 8 weeks of MORE (n = 11) or a support group control condition (n = 18). ERPs to images representing naturally rewarding stimuli (e.g., beautiful landscapes, intimate couples) and neutral images were measured before and after 8 weeks of treatment. Analyses focused on the late positive potential (LPP)--an ERP response in the 400-1,000 ms time window thought to index allocation of attention to emotional information. Treatment with MORE was associated with significant increases in LPP response to natural reward stimuli relative to neutral stimuli which were correlated with enhanced positive affective cue-responses and reductions in opioid craving from pre- to post-treatment. Findings suggest that cognitive training regimens centered on strengthening attention to natural rewards may remediate reward processing deficits underpinning addictive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.