ArticleArthritis care & research2015
Temporal effect of depressive symptoms on the longitudinal evolution of rheumatoid arthritis disease activity.
Article in Arthritis care & research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Longitudinal effects of affective distress on disease outcomes in rheumatoid arthritis: a meta-analysis and systematic review.Rheumatology international · 2024Pooled it
- The Relationship Between Mental Health, Disease Severity, and Genetic Risk for Depression in Early Rheumatoid Arthritis.Psychosomatic medicineTrial
- Towards an individualised approach to pain management in inflammatory arthritis.Therapeutic advances in musculoskeletal disease · 2026Review
- Evaluation of Dynamic Effects of Depressive Symptoms on Physical Function in Knee Osteoarthritis.Arthritis care & research · 2024Article
- The Effect of Meditation, Mindfulness, and Yoga in Patients with Rheumatoid Arthritis.Journal of personalized medicine · 2022Review
- Relationship Between Depression and Disease Activity in United States Veterans With Early Rheumatoid Arthritis Receiving Methotrexate.The Journal of rheumatology · 2021Article
- The burden of pain in rheumatoid arthritis: Impact of disease activity and psychological factors.European journal of pain (London, England) · 2020Article
- Depression Subtypes in Individuals With or at Risk for Symptomatic Knee Osteoarthritis.Arthritis care & research · 2020Observational
- The influence of depression on patient-reported outcomes for hip-fracture patients 1 year after surgery: a prospective cohort study.Aging clinical and experimental research · 2020Observational
- [Higher prevalence of depressive and anxiety symptoms in early arthritis patients in comparison to the normal population].Zeitschrift fur Rheumatologie · 2019Article
- [Depressive symptoms in early rheumatoid arthritis : Within the rheumatism network ADAPTHERA].Zeitschrift fur Rheumatologie · 2019Article
- Pain severity as a mediator of the association between depressive symptoms and physical performance in knee osteoarthritis.Osteoarthritis and cartilage · 2018Observational
- Article
- Dynamic Effects of Depressive Symptoms on Osteoarthritis Knee Pain.Arthritis care & research · 2018Article
- Gender-associated comorbidities in rheumatoid arthritis and their impact on outcome: data from GENIRA.Rheumatology international · 2017Article
- Healthcare burden of depression in adults with arthritis.Expert review of pharmacoeconomics & outcomes research · 2017Review
- Effects of Prefracture Depressive Illness and Postfracture Depressive Symptoms on Physical Performance After Hip Fracture.Journal of the American Geriatrics Society · 2016Observational
- A Prospective Evaluation of the Effects of Prevalent Depressive Symptoms on Disease Activity in Rheumatoid Arthritis Patients Treated With Biologic Response Modifiers.Clinical therapeutics · 2016Article
- Non-inflammatory Causes of Pain in Patients with Rheumatoid Arthritis.Current rheumatology reports · 2016Review
- Depressive symptoms and the risk of arthritis: A survival analysis using data from the osteoarthritis initiative.Indian journal of psychiatryArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveDepression is common in the rheumatoid arthritis (RA) population, yet little is known of its effect on the course of disease activity. The aim of our study was to determine if prevalent and incident depressive symptoms influenced longitudinal changes in RA disease activity.
methodsRA patients with and without depressive symptoms were identified using single-item questions from an existing registry sample. Mixed-effects models were used to examine changes in disease activity over 2 years in those with and without prevalent and incident depressive symptoms. Outcome variables included composite disease activity, joint counts, global assessments, pain, function, and acute-phase reactants. Model-based outcome estimations at the index dates and corresponding 1- and 2-year changes were calculated.
resultsRates of disease activity change were significantly different in patients with a lifetime prevalence of symptomology, but not incident depressive symptoms, when compared to controls. Prior symptoms were associated with slower rates of disease activity decline, evidenced by the estimated 1-year Clinical Disease Activity Index changes: -3.0 (-3.3, -2.6) and -4.0 (-4.3, -3.6) in patients with and without lifetime prevalence, respectively. Analogous results were obtained for most of the other disease activity outcomes; although, there was no temporal effect of prevalent symptoms of depression on swollen joints and acute-phase reactants.
conclusionDepressive symptoms temporally influence the evolution of RA disease activity, and the magnitude is dependent on the time of symptomatic onset. However, the effect is limited to patient-reported pain, global assessment, and function, as well as physician-reported global assessment and tender joints.
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