ArticleThe Journal of biological chemistry2015
Human CHD2 is a chromatin assembly ATPase regulated by its chromo- and DNA-binding domains.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Phosphosite-centric regulatory network of ATAD2 and its involvement in transcriptional networks.Molecular genetics and genomics : MGG · 2026Article
- Evaluation of familial phenotype deviation to measure the impact of de novo mutations in autism.Genome medicine · 2025Article
- Effects of two chd2-knockout strains on the morphology and behavior in zebrafish.Development genes and evolution · 2024Article
- The opportunities and challenges of epigenetic approaches to manage herpes simplex infections.Expert review of anti-infective therapy · 2024Review
- Adult Phenotype ofNeurology. Genetics · 2024Article
- Neurodevelopmental Disorder Caused by Deletion ofThe New England journal of medicine · 2024Article
- Expanding the Mutational Landscape and Clinical Phenotype of CHD2-Related Encephalopathy.Neurology. Genetics · 2024Article
- Advances in epigenetic alterations of chronic lymphocytic leukemia: from pathogenesis to treatment.Clinical and experimental medicine · 2024Review
- Novel syndromic neurodevelopmental disorder caused bymedRxiv : the preprint server for health sciences · 2024Article
- Clinical analysis ofPediatric investigation · 2022Article
- Histone Chaperone Nucleophosmin Regulates Transcription of Key Genes Involved in Oral Tumorigenesis.Molecular and cellular biology · 2022Article
- Clinical Study of 8 Cases ofFrontiers in cell and developmental biology · 2022Article
- Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease.Genes & development · 2021Review
- Major driver mutations are shared between sinonasal intestinal-type adenocarcinoma and the morphologically identical colorectal adenocarcinoma.Journal of cancer research and clinical oncology · 2021Article
- CHD2-Related CNS Pathologies.International journal of molecular sciences · 2021Review
- Resveratrol reduced the detrimental effects of malondialdehyde on human endothelial cells.Journal of cardiovascular and thoracic research · 2021Article
- Chromatin remodeling dysfunction extends the etiological spectrum of schizophrenia: a case report.BMC medical genetics · 2020Article
- Autism-linked CHD gene expression patterns during development predict multi-organ disease phenotypes.Journal of anatomy · 2018Article
- Human CHD1 is required for early DNA-damage signaling and is uniquely regulated by its N terminus.Nucleic acids research · 2018Article
- Nervous system development and disease: A focus on trithorax related proteins and chromatin remodelers.Molecular and cellular neurosciences · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromodomain helicase DNA-binding protein 2 (CHD2) is an ATPase and a member of the SNF2-like family of helicase-related enzymes. Although deletions of CHD2 have been linked to developmental defects in mice and epileptic disorders in humans, little is known about its biochemical and cellular activities. In this study, we investigate the ATP-dependent activity of CHD2 and show that CHD2 catalyzes the assembly of chromatin into periodic arrays. We also show that the N-terminal region of CHD2, which contains tandem chromodomains, serves an auto-inhibitory role in both the DNA-binding and ATPase activities of CHD2. While loss of the N-terminal region leads to enhanced chromatin-stimulated ATPase activity, the N-terminal region is required for ATP-dependent chromatin remodeling by CHD2. In contrast, the C-terminal region, which contains a putative DNA-binding domain, selectively senses double-stranded DNA of at least 40 base pairs in length and enhances the ATPase and chromatin remodeling activities of CHD2. Our study shows that the accessory domains of CHD2 play central roles in both regulating the ATPase domain and conferring selectivity to chromatin substrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.