ReviewThe Journal of physiology2015
Defining inhibitory neurone function in respiratory circuits: opportunities with optogenetics?
Review in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Inhibitory Subpopulations in preBötzinger Complex Play Distinct Roles in Modulating Inspiratory Rhythm and Pattern.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Simultaneous detection of neurotransmitters and CuRSC advances · 2023Article
- Vasopressin and Breathing: Review of Evidence for Respiratory Effects of the Antidiuretic Hormone.Frontiers in physiology · 2021Review
- Adaptation of Respiratory-Related Brain Regions to Long-Term Hypercapnia: Focus on Neuropeptides in the RTN.Frontiers in neuroscience · 2019Article
- Muscarinic Modulation of Morphologically Identified Glycinergic Neurons in the Mouse PreBötzinger Complex.Frontiers in cellular neuroscience · 2019Article
- Defining the Rhythmogenic Elements of Mammalian Breathing.Physiology (Bethesda, Md.) · 2018Review
- Phasic inhibition as a mechanism for generation of rapid respiratory rhythms.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Non-chemosensitive parafacial neurons simultaneously regulate active expiration and airway patency under hypercapnia in rats.The Journal of physiology · 2017Article
- Glycinergic transmission: glycine transporter GlyT2 in neuronal pathologies.Neuronal signaling · 2017Review
- Insights gleaned from pharmaco-genetic dissection and modelling of cardio-respiratory neural networks.The Journal of physiology · 2015Article
- Carotid body overactivity induces respiratory neurone channelopathy contributing to neurogenic hypertension.The Journal of physiology · 2015Review
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Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Pharmacological and mathematical modelling studies support the view that synaptic inhibition in mammalian brainstem respiratory circuits is essential for generating normal and stable breathing movements. GABAergic and glycinergic neurones are known components of these circuits but their precise functional roles have not been established, especially within key microcircuits of the respiratory pre-Bötzinger (pre-BötC) and Bötzinger (BötC) complexes involved in phasic control of respiratory pump and airway muscles. Here, we review briefly current concepts of relevant complexities of inhibitory synapses and the importance of synaptic inhibition in the operation of these microcircuits. We highlight results and limitations of classical pharmacological studies that have suggested critical functions of synaptic inhibition. We then explore the potential opportunities for optogenetic strategies that represent a promising new approach for interrogating function of inhibitory circuits, including a hypothetical wish list for optogenetic approaches to allow expedient application of this technology. We conclude that recent technical advances in optogenetics should provide a means to understand the role of functionally select and regionally confined subsets of inhibitory neurones in key respiratory circuits such as those in the pre-BötC and BötC.
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