ArticleBMJ open2014
Population-based cohort study on the risk of pneumonia in patients with non-traumatic intracranial haemorrhage who use proton pump inhibitors.
Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The impact of proton pump inhibitor exposure on pneumonia: an updated meta-analysis based on randomized controlled trials.Frontiers in pharmacology · 2025Pooled it
- A brain CT-based approach for predicting and analyzing stroke-associated pneumonia from intracerebral hemorrhage.Frontiers in neurology · 2023Article
- A Novel Risk Predictive Scoring Model for Predicting Subsequent Infection After Carbapenem-Resistant Gram-Negative Bacteria Colonization in Hematological Malignancy Patients.Frontiers in oncology · 2022Article
- Article
- Association between Proton Pump Inhibitor Use and CNS Infection Risk: A Retrospective Cohort Study.Journal of clinical medicine · 2018Article
- Proton-Pump Inhibitors and Long-Term Risk of Community-Acquired Pneumonia in Older Adults.Journal of the American Geriatrics Society · 2018Article
- Risk of pneumonia in patients with gastroesophageal reflux disease: A population-based cohort study.PloS one · 2017Article
- Risk of Stroke-Associated Pneumonia With Acid-Suppressive Drugs: A Population-Based Cohort Study.Medicine · 2015Article
- Peer-Led Education Expedites Deprescribing Proton Pump Inhibitors for Appropriate Veterans.Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and AssociatesArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis nationwide cohort study investigated the association between proton pump inhibitor (PPI) usage and the risk of pneumonia in patients with non-traumatic intracranial haemorrhage (ICH).
designNationwide population-based cohort study.
settingLongitudinal Health Insurance Database 2010 (LHID2010) sampled from the Taiwan National Health Insurance Research Database.
participants4644 patients with non-traumatic ICH from 2010 to 2011 were identified. Patients aged <18 years and newly diagnosed with non-traumatic ICH complicated with pneumonia during the same admission period were excluded. A total of 2170 participants were eligible for the final analysis.
main outcome measurePatients using PPIs or not during the study period were tracked to identify the occurrence of any type of pneumonia.
resultsThe adjusted HR of the risk of pneumonia for ICH patients who used PPIs was 1.61 (95% CI 1.32 to 1.97, p<0.001). The risk of pneumonia was positively associated with the administration of PPIs. We observed a greater risk of pneumonia in patients who used PPIs than in those who did not. Moreover, we observed that the risk of pneumonia in patients who used PPIs was 2.60 and 2.04 (95% CI 2.01 to 3.38, p<0.001; 95% CI 1.34 to 3.10, p<0.001) greater than that in patients who did not use PPIs when the defined daily dose was <30 and 30-60, respectively.
conclusionsThe results of this study indicate that the use of PPIs in patients with non-traumatic ICH is associated with an increased risk of pneumonia, and the severity of this risk depends on the defined daily dose. Physicians should exercise caution when prescribing PPIs for patients with non-traumatic ICH.
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