ArticleTissue engineering. Part C, Methods2015
Combined ultrasound and photoacoustic imaging to noninvasively assess burn injury and selectively monitor a regenerative tissue-engineered construct.
Article in Tissue engineering. Part C, Methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- A fast all-optical 3D photoacoustic scanner for clinical vascular imaging.Nature biomedical engineering · 2025Article
- The Potential of Photoacoustic Imaging in Detecting and Managing Complex Wounds.Biomaterials research · 2025Review
- Multimodal optoacoustic imaging: methods and contrast materials.Chemical Society reviews · 2024Review
- Dual-modal Photoacoustic and Ultrasound Imaging: from preclinical to clinical applications.Frontiers in photonics · 2024Article
- A Bacteriophage Microgel Effectively Treats the Multidrug-ResistantPharmaceuticals (Basel, Switzerland) · 2023Article
- Hybrid magnetic resonance and optoacoustic tomography (MROT) for preclinical neuroimaging.Light, science & applications · 2022Article
- Unveiling the improved targeting migration of mesenchymal stem cells with CXC chemokine receptor 3-modification using intravital NIR-II photoacoustic imaging.Journal of nanobiotechnology · 2022Article
- In vivo tracking ofScientific reports · 2021Article
- Recent advances in applications of multimodal ultrasound-guided photoacoustic imaging technology.Visual computing for industry, biomedicine, and art · 2020Review
- Photoacoustic Imaging in Tissue Engineering and Regenerative Medicine.Tissue engineering. Part B, Reviews · 2020Review
- Article
- Monitoring neovascularization and integration of decellularized human scaffolds using photoacoustic imaging.Photoacoustics · 2019Article
- Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis.Drug delivery · 2018Article
- Recent progress in photoacoustic molecular imaging.Current opinion in chemical biology · 2018Review
- Rapid scanning wide-field clutter elimination in epi-optoacoustic imaging using comb LOVIT.Photoacoustics · 2018Article
- Thermal injury of skin and subcutaneous tissues: A review of experimental approaches and numerical models.Burns : journal of the International Society for Burn Injuries · 2017Review
- Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies.NPJ Regenerative medicine · 2017Review
- Preclinical detection of liver fibrosis using dual-modality photoacoustic/ultrasound system.Biomedical optics express · 2016Article
- Quantitative Ultrasound for Nondestructive Characterization of Engineered Tissues and Biomaterials.Annals of biomedical engineering · 2016Review
- Non-invasive Assessments of Adipose Tissue Metabolism In Vitro.Annals of biomedical engineering · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Current biomedical imaging tools have limitations in accurate assessment of the severity of open and deep burn wounds involving excess bleeding and severe tissue damage. Furthermore, sophisticated imaging techniques are needed for advanced therapeutic approaches such as noninvasive monitoring of stem cells seeded and applied in a biomedical 3D scaffold to enhance wound repair. This work introduces a novel application of combined ultrasound (US) and photoacoustic (PA) imaging to assess both burn injury and skin tissue regeneration. Tissue structural damage and bleeding throughout the epidermis and dermis till the subcutaneous skin layer were imaged noninvasively by US/PA imaging. Gold nanoparticle-labeled adipose-derived stem cells (ASCs) within a PEGylated fibrin 3D gel were implanted in a rat model of cutaneous burn injury. ASCs were successfully tracked till 2 weeks and were distinguished from host tissue components (e.g., epidermis, fat, and blood vessels) through spectroscopic PA imaging. The structure and function of blood vessels (vessel density and perfusion) in the wound bed undergoing skin tissue regeneration were monitored both qualitatively and semi-quantitatively by the developed imaging approach. Imaging-based analysis demonstrated ASC localization in the top layer of skin and a higher density of regenerating blood vessels in the treated groups. This was corroborated with histological analysis showing localization of fluorescently labeled ASCs and smooth muscle alpha actin-positive blood vessels. Overall, the US/PA imaging-based strategy coupled with gold nanoparticles has a great potential for stem cell therapies and tissue engineering due to its noninvasiveness, safety, selectivity, and ability to provide long-term monitoring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.