ArticleTechniques in coloproctology2015
Outcome and prognostic factors of local recurrent rectal cancer: a pooled analysis of 150 patients.
Article in Techniques in coloproctology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 34 citations in OpenAlex.
- Prospective longitudinal trajectory of cancer survivorship among patients with recurrent rectal cancer: impact of treatment modalities and resection status.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
- Recurrent rectal cancer cured by transsacral prone longitudinal incision combined with bilateral gluteus maximus "kite" flap filling: a case report.Frontiers in oncology · 2025Article
- Role of 18F-PET-CT to predict pathological response after neoadjuvant treatment of rectal cancer.Discover oncology · 2021Article
- Neoadjuvant Chemoradiation Combined with Regional Hyperthermia in Locally Advanced or Recurrent Rectal Cancer.Cancers · 2021Article
- Predictors of short-term readmission after beyond total mesorectal excision for primary locally advanced and recurrent rectal cancer.Updates in surgery · 2019Article
- Pelvic exenterations for primary rectal cancer: Analysis from a 10-year national prospective database.World journal of gastroenterology · 2018Article
- Outcomes and prognostic factors of multimodality treatment for locally recurrent rectal cancer with curative intent.International journal of colorectal disease · 2018Article
- Prognostic significance of pathological response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer.International journal of clinical oncology · 2016Article
- Consequences of defensive medicine, second victims, and clinical-judicial syndrome on surgeons' medical practice and on health service.Updates in surgery · 2015Review
- Hormonal contraceptives and venous thromboembolism: Are inflammatory bowel disease patients at increased risk? A retrospective study on a prospective database.Annals of medicine and surgery (2012) · 2015Article
- Colorectal surgery in a rural setting.Updates in surgery · 2015Article
- In reply to Tin et al.International journal of colorectal disease · 2015Article
- Prophylactic negative pressure wound therapy in colorectal surgery. Effects on surgical site events: current status and call to action.Updates in surgery · 2015Review
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgery is the only curative treatment in patients with locally recurrent rectal cancer (LRRC). The aim of this study was to evaluate the outcome and the prognostic factors of tumour-free resection margin (R0) and overall survival (OS) in LRRC.
methodsConsecutive LRRC patients observed between 1987 and 2005 in three Italian university hospitals were evaluated. Survival curves were estimated using the Kaplan-Meier method and compared with the log-rank test. In order to identify factors associated with both R0 resection and OS, a logistic regression analysis was performed in patients who underwent surgery with curative intent.
resultsOut of 150 patients with LRRC, 107 underwent surgery, but since 7 were found to have unresectable disease only 100 underwent surgical resection. Of them, 51 underwent radical and 49 extended resection. Sixty of the 107 patients underwent multimodality treatment. In 61 patients, R0 resection was achieved. Median OS after surgery was 43.4 months. In patients, who had surgery with curative intent, independent variables associated with R0 resection were: surgery for the primary tumour performed in other hospitals (p = 0.042) extended resection (p = 0.025) and use of positron emission tomography (PET) as a staging modality (p = 0.03). Independent variables associated with OS were: post-operative radiotherapy (p = 0.004), stage of the primary tumour (p = 0.004), R0 resection (p = 0.00001), and use of PET (0.02).
conclusionsResection for LRRC results in improved survival. Other than the well-known prognostic factors R0 resection and OS, PET scan has an independent impact both on OS and R0 resection. It should therefore be included in routine clinical practice when staging LRRC.
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