Trial reportJournal of abnormal psychology2015
Anhedonia as a component of the tobacco withdrawal syndrome.
Trial report in Journal of abnormal psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02844595 (Behavioural Activation Treatment for Smoking Cessation and Depressive Symptomatology), which is not on this map. Cited by 54 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Behavioural Activation Treatment for Smoking Cessation and Depressive Symptomatology: a Randomized Controlled Trial
Who cites it
54 citing papers in PubMed, 6 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation.The Cochrane database of systematic reviews · 2023Pooled it
- The Promise of Polygenic Risk Prediction in Smoking Cessation: Evidence From Two Treatment Trials.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Pooled it
- Assessment of Anhedonia in Adults With and Without Mental Illness: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Possible New Symptoms of Tobacco Withdrawal II: Anhedonia-A Systematic Review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Pooled it
- Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation.The Cochrane database of systematic reviews · 2019Pooled it
- Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model.Addiction (Abingdon, England) · 2017Pooled it
- Time-varying mediated effects of the nicotine patch on smoking before and after a quit attempt when it is added to varenicline and counseling.Drug and alcohol dependence · 2026Trial
- Acute Effects of Nicotine on Non-Drug-Related Reward in Smokers and Non-Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Trial
- Development of a targeted behavioral treatment for smoking cessation among individuals with Chronic Obstructive Pulmonary Disease.Journal of behavioral medicine · 2023Trial
- Time-varying effects of 'optimized smoking treatment' on craving, negative affect and anhedonia.Addiction (Abingdon, England) · 2021Trial
- Very Low Nicotine Content Cigarettes Disrupt the Feedback Loop of Affective States and Smoking Behavior.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Trial
- Cost-effectiveness and cost-utility analysis of a work-place smoking cessation intervention with and without financial incentives.Addiction (Abingdon, England) · 2020Trial
- Bupropion increases activation in nucleus accumbens during anticipation of monetary reward.Psychopharmacology · 2019Trial
- Anhedonia: Its Dynamic Relations With Craving, Negative Affect, and Treatment During a Quit Smoking Attempt.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Trial
- Toward precision smoking cessation treatment I: Moderator results from a factorial experiment.Drug and alcohol dependence · 2017Trial
- What a difference a day makes: differences in initial abstinence response during a smoking cessation attempt.Addiction (Abingdon, England) · 2017Trial
- Is the Effect of Anhedonia on Smoking Cessation Greater for Women Versus Men?Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Trial
- Longitudinal changes in smoking abstinence symptoms and alternative reinforcers predict long-term smoking cessation outcomes.Drug and alcohol dependence · 2016Trial
- Identifying effective intervention components for smoking cessation: a factorial screening experiment.Addiction (Abingdon, England) · 2016Trial
- Pharmacological, sensorimotor, and expectancy effects on tobacco withdrawal: a preliminary study.Human psychopharmacology · 2015Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Animal research suggests that anhedonia is a tobacco withdrawal symptom, but this topic has not been addressed definitively in research with humans. This research sought to determine whether anhedonia is (a) an element of the tobacco withdrawal syndrome in humans and (b) an impediment to successful tobacco cessation. Data were from 1,175 smokers (58.3% women; 85.5% White) participating in a randomized double-blind, placebo-controlled trial of smoking cessation pharmacotherapies. Ecological momentary assessments for 5 days before and 10 days after the target quit day were used to assess anhedonia and other established withdrawal symptoms. Consistent with drug withdrawal, anhedonia showed an inverted-U pattern of change in response to tobacco cessation and was associated with the severity of other withdrawal symptoms and tobacco dependence. Postquit anhedonia was associated with decreased latency to relapse (hazard ratio = 1.09, 95% confidence interval [CI] [1.02, 1.17]) and with lower 8-week point-prevalence abstinence (odds ratio = .91, 95% CI [.86, .97])-relations that remained significant when other withdrawal symptoms were included as predictors. Finally, nicotine replacement therapy nearly fully suppressed the increase in abstinence-related anhedonia (β = -.66, p < .001), suggesting agonist suppression of withdrawal. Results suggest that anhedonia is a unique and motivationally significant element of the tobacco withdrawal syndrome in humans. These results have implications for defining and assessing tobacco use disorder and for understanding and treating tobacco addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.