ArticlePloS one2014
Association of brain-derived neurotrophic factor gene Val66Met polymorphism with primary dysmenorrhea.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The genetics of primary dysmenorrhoea: a systematic review.Reproduction & fertility · 2026Pooled it
- Unaltered intrinsic functional brain architecture in young women with primary dysmenorrhea.Scientific reports · 2018Trial
- Untargeted UHPLC-Q-Exactive Orbitrap MS and Targeted UHPLC-QqQ-MS/MS for Exploring the Effective Components of "Wen Tong Plaster" Cataplasm in Treating Rats With Primary Dysmenorrhea.Journal of separation science · 2026Article
- The prevalence and associated risk factors of primary dysmenorrhea among women in Beijing: a cross-sectional study.Scientific reports · 2025Article
- Scientific Knowledge Graph of Dysmenorrhea: A Bibliometric Analysis from 2001 to 2021.Journal of pain research · 2023Article
- Adaptive neuroplasticity in the default mode network contributing to absence of central sensitization in primary dysmenorrhea.Frontiers in neuroscience · 2023Article
- Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment olfaction.Scientific reports · 2022Article
- Article
- Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition From Acute to Chronic Low Back Pain.The Clinical journal of pain · 2020Article
- Dysmenorrhea and Associated Factors among Polish Women: A Cross-Sectional Study.Pain research & management · 2020Article
- Polycystic ovarian morphology is associated with primary dysmenorrhea in young Korean women.Obstetrics & gynecology science · 2019Article
- Experimental evaluation of central pain processes in young women with primary dysmenorrhea.Pain · 2019Article
- Partners in Crime: NGF and BDNF in Visceral Dysfunction.Current neuropharmacology · 2019Review
- Correlation Between Thalamus-Related Functional Connectivity and Serum BDNF Levels During the Periovulatory Phase of Primary Dysmenorrhea.Frontiers in human neuroscience · 2019Article
- Interactions ofFrontiers in neuroscience · 2018Article
- Encoding of menstrual pain experience with theta oscillations in women with primary dysmenorrhea.Scientific reports · 2017Article
- Common variants in ZMIZ1 and near NGF confer risk for primary dysmenorrhoea.Nature communications · 2017Article
- Experimental and procedural pain responses in primary dysmenorrhea: a systematic review.Journal of pain research · 2017Review
- Mental Health Comorbidities in Pediatric Chronic Pain: A Narrative Review of Epidemiology, Models, Neurobiological Mechanisms and Treatment.Children (Basel, Switzerland) · 2016Review
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary dysmenorrhea (PDM), the most prevalent menstrual cycle-related problem in women of reproductive age, is associated with negative moods. Whether the menstrual pain and negative moods have a genetic basis remains unknown. Brain-derived neurotrophic factor (BDNF) plays a key role in the production of central sensitization and contributes to chronic pain conditions. BDNF has also been implicated in stress-related mood disorders. We screened and genotyped the BDNF Val66Met polymorphism (rs6265) in 99 Taiwanese (Asian) PDMs (20-30 years old) and 101 age-matched healthy female controls. We found that there was a significantly higher frequency of the Met allele of the BDNF Val66Met polymorphism in the PDM group. Furthermore, BDNF Met/Met homozygosity had a significantly stronger association with PDM compared with Val carrier status. Subsequent behavioral/hormonal assessments of sub-groups (PDMs = 78, controls = 81; eligible for longitudinal multimodal neuroimaging battery studies) revealed that the BDNF Met/Met homozygous PDMs exhibited a higher menstrual pain score (sensory dimension) and a more anxious mood than the Val carrier PDMs during the menstrual phase. Although preliminary, our study suggests that the BDNF Val66Met polymorphism is associated with PDM in Taiwanese (Asian) people, and BDNF Met/Met homozygosity may be associated with an increased risk of PDM. Our data also suggest the BDNF Val66Met polymorphism as a possible regulator of menstrual pain and pain-related emotions in PDM. Absence of thermal hypersensitivity may connote an ethnic attribution. The presentation of our findings calls for further genetic and neuroscientific investigations of PDM.
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