ArticleNature genetics2014
Variation at HLA-DRB1 is associated with resistance to enteric fever.
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Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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64citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
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- A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy.American journal of human genetics · 2024Article
- Fine mapping identifies independent HLA associations in autoimmune hepatitis type 1.JHEP reports : innovation in hepatology · 2024Article
- Typhoid fever.Nature reviews. Disease primers · 2023Review
- Accurate prediction of HLA class II antigen presentation across all loci using tailored data acquisition and refined machine learning.Science advances · 2023Article
- Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection.Scientific reports · 2023Article
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- The role of tissue resident memory CD4 T cells in Salmonella infection: Implications for future vaccines.Vaccine · 2023Review
- TheMicrobiology (Reading, England) · 2023Article
- Associations between HLA class II alleles and IgE sensitization to allergens in the Qatar Biobank cohort.The journal of allergy and clinical immunology. Global · 2023Article
- Human variation impactingCell genomics · 2023Article
- One species, different diseases: the unique molecular mechanisms that underlie the pathogenesis of typhoidal Salmonella infections.Current opinion in microbiology · 2023Review
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- Historic and Prehistoric Epidemics: An Overview of Sources Available for the Study of Ancient Pathogens.Epidemiologia (Basel, Switzerland) · 2022Review
- Genetic Susceptibility to Enteric Fever in Experimentally Challenged Human Volunteers.Infection and immunity · 2022Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
36 authors at 15 institutions in 8 countries.
Sarah J Dunstan1] Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. [2] Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK. [3] Nossal Institute of Global Health, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 000000017873933X
Nguyen Thi Hue1] Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. [2] Faculty of Biology, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam.
Buhm Han1] Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. [2] Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [4] Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA.
Zheng LiGenome Institute of Singapore, Singapore.
Trinh Thi Bich TramOxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Kar Seng SimGenome Institute of Singapore, Singapore.ORCID 0000000238227759
Christopher M Parry1] Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. [2] Liverpool School of Tropical Medicine, Liverpool, UK.
Nguyen Tran ChinhHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Ha VinhHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Nguyen Phu Huong LanHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Nga Tran Vu ThieuOxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Phat Voong VinhOxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Samir KoiralaOxford University Clinical Research Unit-Nepal, Patan Academy of Health Sciences, Patan Hospital, Patan, Nepal.
Sabina DongolOxford University Clinical Research Unit-Nepal, Patan Academy of Health Sciences, Patan Hospital, Patan, Nepal.
Amit ArjyalOxford University Clinical Research Unit-Nepal, Patan Academy of Health Sciences, Patan Hospital, Patan, Nepal.
Abhilasha KarkeyOxford University Clinical Research Unit-Nepal, Patan Academy of Health Sciences, Patan Hospital, Patan, Nepal.
Olita ShilpakarOxford University Clinical Research Unit-Nepal, Patan Academy of Health Sciences, Patan Hospital, Patan, Nepal.
Christiane Dolecek1] Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. [2] Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK.
Jia Nee FooGenome Institute of Singapore, Singapore.ORCID 0000000198992308
Le Thi PhuongDong Thap Provincial Hospital, Cao Lanh, Vietnam.
Mai Ngoc LanhDong Thap Provincial Hospital, Cao Lanh, Vietnam.
Tan DoVietnam National Institute of Ophthalmology, Hanoi, Vietnam.
Tin AungSingapore Eye Research Institute, Singapore.
Do Nu HonVietnam National Institute of Ophthalmology, Hanoi, Vietnam.
Yik Ying Teo1] Department of Statistics and Applied Probability, National University of Singapore, Singapore. [2] Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Martin L Hibberd1] Genome Institute of Singapore, Singapore. [2] London School of Tropical Medicine and Hygiene, London, UK.
Katherine L Anders1] Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. [2] Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK.
Yukinori Okada1] Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. [2] Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Soumya Raychaudhuri1] Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [3] Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA. [4] Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA. [5] Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.
Cameron P Simmons1] Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. [2] Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK. [3] Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria, Australia.
Stephen Baker1] Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. [2] Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK. [3] London School of Tropical Medicine and Hygiene, London, UK.
Paul I W de Bakker1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
Buddha BasnyatOxford University Clinical Research Unit-Nepal, Patan Academy of Health Sciences, Patan Hospital, Patan, Nepal.
Tran Tinh HienOxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Jeremy J Farrar1] Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam. [2] Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, UK.
Chiea Chuen Khor1] Genome Institute of Singapore, Singapore. [2] Singapore Eye Research Institute, Singapore. [3] Saw Swee Hock School of Public Health, National University of Singapore, Singapore. [4] Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. [5] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Patan Academy of Health Sciences · NPAngkor Hospital for Children · KHOxford University Clinical Research Unit · VNGenome Institute of Singapore · SGHospital for Tropical Diseases · VNDong Thap Hospital · VNNational University of Singapore · SGVietnam National Children's Hospital · VNBrigham and Women's Hospital · USLiverpool School of Tropical Medicine · GBMass General Brigham · USSingapore Eye Research Institute · SGTokyo Medical and Dental University · JPUniversity Medical Center Utrecht · NLVietnam National University Ho Chi Minh City · VN
Funding
Fine-mapping the MHC associations in rheumatoid arthritis from GWAS dataR01AR062886 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI RAYCHAUDHURI, SOUMYA · 2012 to 2013
$783kNIAMS NIH HHS R01 AR062886Wellcome Trust 089276Wellcome Trust 089276/Z/09/ZWellcome Trust 100087Wellcome Trust 100087/Z/12/Z
Abstract
Enteric fever affects more than 25 million people annually and results from systemic infection with Salmonella enterica serovar Typhi or Paratyphi pathovars A, B or C(1). We conducted a genome-wide association study of 432 individuals with blood culture-confirmed enteric fever and 2,011 controls from Vietnam. We observed strong association at rs7765379 (odds ratio (OR) for the minor allele = 0.18, P = 4.5 × 10(-10)), a marker mapping to the HLA class II region, in proximity to HLA-DQB1 and HLA-DRB1. We replicated this association in 595 enteric fever cases and 386 controls from Nepal and also in a second independent collection of 151 cases and 668 controls from Vietnam. Imputation-based fine-mapping across the extended MHC region showed that the classical HLA-DRB1*04:05 allele (OR = 0.14, P = 2.60 × 10(-11)) could entirely explain the association at rs7765379, thus implicating HLA-DRB1 as a major contributor to resistance against enteric fever, presumably through antigen presentation.
Indexed as
AllelesAntigen PresentationBiomarkersChromosome MappingGenetic MarkersGenetic Predisposition to DiseaseGenotypeHLA-DRB1 ChainsHumansModels, StatisticalNepalOdds RatioPolymorphism, Single NucleotidePrincipal Component AnalysisRegression AnalysisTyphoid FeverBiomarkersGenetic MarkersHLA-DRB1*04 antigenHLA-DRB1 Chains
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