ArticleNature neuroscience2014
Molecular and functional definition of the developing human striatum.
Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Targeting UCHL3 attenuates pathological markers in neuronal models of Huntington's disease.Brain : a journal of neurology · 2026Article
- Metabolic trajectories in developing human neocortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Systematic scRNA-seq screens profile neural organoid response to morphogens.Nature methods · 2026Article
- 3D cultured human medium spiny neurons functionally integrate and rescue motor deficits in Huntington's disease mice.The Journal of clinical investigation · 2025Article
- Mouse and human striatal projection neurons compared - somatodendritic arbor, spines and in silico analyses.PLoS computational biology · 2025Article
- Transcriptomic profiles link corticostriatal microarchitecture to genetics of neurodevelopment and neuropsychiatric risks.Translational psychiatry · 2025Article
- Huntington's disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids.Nature communications · 2024Article
- Article
- EBF1 is a potential biomarker for predicting progression from mild cognitive impairment to Alzheimer's disease: anFrontiers in aging neuroscience · 2024Article
- In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids.Nature methods · 2023Article
- Article
- Differentiation of hPSCs to Study PRC2 Role in Cell-Fate Specification and Neurodevelopment.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Article
- Human striatal organoids derived from pluripotent stem cells recapitulate striatal development and compartments.PLoS biology · 2022Article
- Brain Regional Identity and Cell Type Specificity Landscape of Human Cortical Organoid Models.International journal of molecular sciences · 2022Article
- Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes.Nature communications · 2022Article
- Postnatal Conditional Deletion ofBiomedicines · 2022Article
- Modularity of the Human Musculoskeletal System: The Correlation between Functional Structures by Computer Tools Analysis.Life (Basel, Switzerland) · 2022Article
- Zika virus induces FOXG1 nuclear displacement and downregulation in human neural progenitors.Stem cell reports · 2022Article
- A Distinct Metabolically Defined Central Nucleus Circuit Bidirectionally Controls Anxiety-Related Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complexity of the human brain derives from the intricate interplay of molecular instructions during development. Here we systematically investigated gene expression changes in the prenatal human striatum and cerebral cortex during development from post-conception weeks 2 to 20. We identified tissue-specific gene coexpression networks, differentially expressed genes and a minimal set of bimodal genes, including those encoding transcription factors, that distinguished striatal from neocortical identities. Unexpected differences from mouse striatal development were discovered. We monitored 36 determinants at the protein level, revealing regional domains of expression and their refinement, during striatal development. We electrophysiologically profiled human striatal neurons differentiated in vitro and determined their refined molecular and functional properties. These results provide a resource and opportunity to gain global understanding of how transcriptional and functional processes converge to specify human striatal and neocortical neurons during development.
Indexed as
Identifiers
25383901What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.