ArticleJournal of neuropathology and experimental neurology2014
The calcium-binding protein EFhd2 modulates synapse formation in vitro and is linked to human dementia.
Article in Journal of neuropathology and experimental neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- EFHD2 cooperates with E3 ubiquitin ligase Smurf1 to facilitate virus infection by promoting the degradation of TRAF6 in teleost fish.Journal of virology · 2024Article
- New insights into hypothalamic neurogenesis disruption after acute and intense stress: implications for microglia and inflammation.Frontiers in neuroscience · 2023Article
- EFhd2 brain interactome reveals its association with different cellular and molecular processes.Journal of neurochemistry · 2021Article
- Swiprosin-1 deficiency in macrophages alleviated atherogenesis.Cell death discovery · 2021Article
- Dysregulated gene-associated biomarkers for Alzheimer's disease and aging.Translational neuroscience · 2021Article
- Association betweenThe Journal of international medical research · 2020Article
- The Use of Whole Exome Sequencing in a Cohort of Transgender Individuals to Identify Rare Genetic Variants.Scientific reports · 2019Article
- Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer's disease.Nature communications · 2018Article
- EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction.Molecular psychiatry · 2018Article
- Impact of Swiprosin-1/Efhd2 on Adult Hippocampal Neurogenesis.Stem cell reports · 2018Article
- Low level of swiprosin-1/EFhd2 in vestibular nuclei of spontaneously hypersensitive motion sickness mice.Scientific reports · 2017Article
- Antioxidants Rescue Mitochondrial Transport in Differentiated Alzheimer's Disease Trans-Mitochondrial Cybrid Cells.Journal of Alzheimer's disease : JAD · 2016Article
- Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system.The Biochemical journal · 2016Review
- EFhd2, a Protein Linked to Alzheimer's Disease and Other Neurological Disorders.Frontiers in neuroscience · 2016Review
- Exploring Potential Biomarkers Underlying Pathogenesis of Alzheimer's Disease by Differential Co-expression Analysis.Avicenna journal of medical biotechnologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
EFhd2 is a calcium-binding adaptor protein that has been found to be associated with pathologically aggregated tau in the brain in Alzheimer disease and in a mouse model of frontotemporal dementia. EFhd2 has cell type-specific functions, including the modulation of intracellular calcium responses, actin dynamics, and microtubule transport. Here we report that EFhd2 protein and mRNA levels are reduced in human frontal cortex tissue affected by different types of dementia with and without tau pathology. We show that EFhd2 is mainly a neuronal protein in the brain and is abundant in the forebrain. Using short hairpin RNA-mediated knockdown of EFhd2 expression in cultured cortical neurons, we demonstrate that loss of EFhd2 affects the number of synapses developed in vitro whereas it does not alter neurite outgrowth per se. Our data suggest that EFhd2 is involved in the control of synapse development and maintenance through means other than affecting neurite development. The changes in expression levels observed in human dementias might, therefore, play a significant role in disease onset and progression of dementia, which is characterized by the loss of synapses.
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