Evidence map›Paper›PMID 25383317›Full record

ArticleMedical mycology case reports2014

Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole.

Jia Chen, Feng Chen, Ying Wang, Ling-Yi Yang, Miao Miao, Yue Han, De-Pei Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical mycology case reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Detection of invasiveAccess microbiology · 2021
    Article
  3. Review
  4. Successful treatment of breakthrough disseminatedMedical mycology case reports · 2018
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jia ChenJiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
Feng ChenJiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
Ying WangJiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
Ling-Yi YangRespiratory Department, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Miao MiaoJiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
Yue HanJiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
De-Pei WuJiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
Soochow University · CNFirst Affiliated Hospital of Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trichosporon species is an important life-threatening opportunistic systemic pathogen, especially in leukemia patients. Voriconazole is proved to be a promising agent in past decade. However, recently we observed a case of breakthrough Trichosporon asahii infection while receiving voriconazole, which calls for an alternative treatment strategy. A combination therapy of liposomal amphotericin B (AmB) plus caspofungin - in which liposomal AmB dose was reduced due to renal toxicity - was administered to successfully treat this patient.

Indexed as

CaspofunginLiposomal amphotericin BT. asahiiVoriconazole

Identifiers

PMID25383317
PMCPMC4223824
OpenAlexW1964518770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.