ArticleJournal of addiction research & therapy2013
Differential Expression of miR-130a in Postmortem Prefrontal Cortex of Subjects with Alcohol Use Disorders.
Article in Journal of addiction research & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- A systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder.Molecular psychiatry · 2025Pooled it
- Noncoding RNA and Alcohol Use Disorder: A Scoping Review of Current Research and Knowledge Gaps.Alcohol research : current reviews · 2025Article
- Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury.International journal of molecular sciences · 2023Review
- Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder.International journal of biological sciences · 2023Review
- A novel microRNA, novel-m009C, regulates methamphetamine rewarding effects.Molecular psychiatry · 2022Article
- Noncoding RNA therapeutics for substance use disorder.Advances in drug and alcohol research · 2022Article
- Targeting Epigenetic Mechanisms to Treat Alcohol Use Disorders (AUD).Current pharmaceutical design · 2021Article
- Exploration of alcohol use disorder-associated brain miRNA-mRNA regulatory networks.Translational psychiatry · 2021Article
- Chronic Voluntary Ethanol Drinking in Cynomolgus Macaques Elicits Gene Expression Changes in Prefrontal Cortical Area 46.Alcoholism, clinical and experimental research · 2020Article
- Salivary microRNAs identified by small RNA sequencing and machine learning as potential biomarkers of alcohol dependence.Epigenomics · 2019Article
- Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain.PloS one · 2018Article
- Emerging roles for ncRNAs in alcohol use disorders.Alcohol (Fayetteville, N.Y.) · 2017Review
- The Potential Role of Amygdaloid MicroRNA-494 in Alcohol-Induced Anxiolysis.Biological psychiatry · 2016Article
- The NSW brain tissue resource centre: Banking for alcohol and major neuropsychiatric disorders research.Alcohol (Fayetteville, N.Y.) · 2016Article
- Ethanol upregulates NMDA receptor subunit gene expression in human embryonic stem cell-derived cortical neurons.PloS one · 2015Article
- Epigenetic Insights into Substance Use Disorder and Associated Psychiatric Conditions.Complex psychiatryReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEmerging evidence suggests that neuroadaptations to alcohol may result from chronic alcohol consumption-induced expression changes of microRNAs (miRNAs) and their target genes. Studies with animal or cell culture models have demonstrated that ethanol exposure leads to miRNA expression alterations. However, there is limited information on miRNA expression in the brains of subjects with alcohol use disorders (AUDs). The present study aimed to analyze expression changes of miRNAs and their target genes in postmortem prefrontal cortex (PFC) of AUD subjects.
methodsGenome-wide miRNA and mRNA expression was examined in postmortem PFC of 23 European Australia AUD cases and 23 matched controls using the Illumina HumanHT-12 v4 Expression BeadChip array, which targets 43,270 coding transcripts and 3,961 non-coding transcripts (including 574 miRNA transcripts). Multiple linear regression analysis and permutation test were performed to identify differentially expressed miRNAs and their target mRNAs. Target gene prediction, Gene Set Enrichment Analysis (GESA), and DAVID functional annotation clustering analysis were applied to identify AUD-associated gene sets and biological modules.
resultsTwo miRNAs and 787 coding genes were differentially expressed in the PFC of AUD cases [miR-130a (downregulated):
conclusionThis study provides evidence that downregulation of miR-130a may lead to altered expression of a number of genes in the PFC of AUD subjects. Further studies are warranted to confirm these findings in replication samples and other reward-related brain regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.