ReviewInternational journal of medicinal chemistry2014
Therapeutic potential of hydrazones as anti-inflammatory agents.
Review in International journal of medicinal chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 94 citations in OpenAlex.
- Synthesis, characterization, and DNA binding of Ni(II), Cu(II), and Zn(II) complexes with a novel N,O-bidentate acylhydrazone.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Design, Synthesis, and Integrated In Silico and In Vitro Evaluation of Chloro-Substituted Salicylaldehyde Benzoylhydrazones as Anticancer Agents.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Biological Activity and Structure-Activity Relationship of Mono- and Bis-Derivatives of 3-(Arylamino)propanehydrazides.Biomolecules · 2026Article
- Novel Experimental Therapeutic Approaches in Glioma-New Hydrazide-Hydrazones as Chemical Agents Sensitizing Glioblastoma Cell Line to Radiotherapy.International journal of molecular sciences · 2026Article
- Catalyst-Free Assembly of δ-Lactam-Based Hydrazide-Hydrazone Compounds from 3-Arylglutaconic Anhydrides and Aldazines.International journal of molecular sciences · 2025Article
- Advancements in Hydrazide-Based HDAC Inhibitors: A Review of Recent Developments and Therapeutic Potential.Journal of medicinal chemistry · 2025Review
- Antimicrobial and Anti-Inflammatory Activity ofPharmaceutics · 2025Article
- Pharmacological Evaluation of Novel Hydrazide and Hydrazone Derivatives: Anti-Inflammatory and Analgesic Potential in Preclinical Models.Molecules (Basel, Switzerland) · 2025Article
- Synthesis, characterization, andFrontiers in pharmacology · 2025Article
- Synthesis, crystal structure and Hirshfeld surface analysis of [Cu(HActa crystallographica. Section E, Crystallographic communications · 2024Article
- Design, synthesis, pharmacological evaluation, andRSC advances · 2024Article
- Design, synthesis, electrochemistry and anti-trypanosomatid hit/lead identification of nitrofuranylazines.RSC medicinal chemistry · 2023Article
- Synthesis and crystal structures of (Acta crystallographica. Section E, Crystallographic communications · 2023Article
- Molecular Hybridization Strategy on the Design, Synthesis, and Structural Characterization of Ferrocene-Molecules (Basel, Switzerland) · 2022Article
- Cytotoxic Activity and Docking Studies of 2-arenoxybenzaldehyde N-acyl Hydrazone and 1,3,4-Oxadiazole Derivatives against Various Cancer Cell Lines.Molecules (Basel, Switzerland) · 2022Article
- ThePharmaceuticals (Basel, Switzerland) · 2022Article
- Biological Evaluation and Molecular Docking Studies of Novel 1,3,4-Oxadiazole Derivatives of 4,6-Dimethyl-2-sulfanylpyridine-3-carboxamide.International journal of molecular sciences · 2022Article
- TridentateFrontiers in neurology · 2022Article
- Antinociceptive and anti-inflammatory effects of hydrazone derivatives and their possible mechanism of action in mice.PloS one · 2021Article
- Construction of a novel quinoxaline as a new class of Nrf2 activator.BMC chemistry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrazones are a special class of organic compounds in the Schiff base family. Hydrazones constitute a versatile compound of organic class having basic structure (R1R2C=NNR3R4). The active centers of hydrazone, that is, carbon and nitrogen, are mainly responsible for the physical and chemical properties of the hydrazones and, due to the reactivity toward electrophiles and nucleophiles, hydrazones are used for the synthesis of organic compound such as heterocyclic compounds with a variety of biological activities. Hydrazones and their derivatives are known to exhibit a wide range of interesting biological activities like antioxidant, anti-inflammatory, anticonvulsant, analgesic, antimicrobial, anticancer, antiprotozoal, antioxidant, antiparasitic, antiplatelet, cardioprotective, anthelmintic, antidiabetic, antitubercular, trypanocidal, anti-HIV, and so forth. The present review summarizes the efficiency of hydrazones as potent anti-inflammatory agents.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.