ReviewJournal of thoracic disease2014
Approach to chronic cough: the neuropathic basis for cough hypersensitivity syndrome.
Review in Journal of thoracic disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Efficacy and safety of superior laryngeal nerve block in neurogenic cough: A systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- An update and systematic review on drug therapies for the treatment of refractory chronic cough.Expert opinion on pharmacotherapy · 2018Pooled it
- Cough desensitization treatment for patients with refractory chronic cough: results of a second pilot randomized control trial.BMC pulmonary medicine · 2023Trial
- Efficacy and safety of Maekmoondong-tang for chronic dry cough: a study protocol for a randomized controlled trial.BMC complementary and alternative medicine · 2016Trial
- Beyond Pain Intensity: A Patient-Informed Framework for Documenting Burden in Small Fiber Neuropathy.Neurology and therapy · 2026Review
- Evaluation of Superior Laryngeal Nerve Block for Management of Laryngeal Sensory Neuropathy.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Prevalence and risk factors of chronic cough in an adult community-dwelling Portuguese population.ERJ open research · 2025Article
- WAO - ARIA consensus on chronic cough: Executive summary.The World Allergy Organization journal · 2025Review
- Article
- Cerebellar ataxia, neuropathy and vestibular areflexia syndrome: a neurogenic cough prototype.ERJ open research · 2024Article
- Association of selected inflammatory biomarkers with cough reflex sensitivity in asthmatic children.Physiological research · 2023Article
- Chronic cough in postmenopausal women and its associations to climacteric symptoms.BMC women's health · 2023Article
- Cough syncope due to laryngeal herpes zoster successfully managed by pregabalin.Archives of medical science : AMS · 2023Article
- Cough desensitization treatment: A randomized, sham-controlled pilot trial for patients with refractory chronic cough.Respiratory medicine · 2022Review
- WAO-ARIA consensus on chronic cough - Part 1: Role of TRP channels in neurogenic inflammation of cough neuronal pathways.The World Allergy Organization journal · 2021Review
- Prostaglandin ERespiratory research · 2021Article
- The Toxicity of Wiped Dust and Airborne Microbes in Individual Classrooms Increase the Risk of Teachers' Work-Related Symptoms: A Cross-Sectional Study.Pathogens (Basel, Switzerland) · 2021Article
- Is laryngeal hypersensitivity the basis of unexplained or refractory chronic cough?ERJ open research · 2021Article
- Cough-Related Laryngeal Sensations and Triggers in Adults With Chronic Cough: Symptom Profile and Impact.Allergy, asthma & immunology research · 2019Article
- Cough responses to inhaled irritants are enhanced by eosinophil major basic protein in awake mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic cough is a common symptom that can be difficult to manage because associated causes may remain elusive and treatment of any associated cause may not provide relief. Current antitussives have limited efficacy and undesirable side-effects. Patients with chronic cough describe sensory symptoms suggestive of upper airway and laryngeal neural dysfunction, and report cough triggered by low-level physical and chemical stimuli supporting the concept of cough reflex hypersensitivity. Mechanisms underlying peripheral and central augmentation of the afferent cough pathways have been identified. Chronic cough is a neuropathic condition that could be secondary to sensory nerve damage caused by inflammatory, infective and allergic factors. Recent success in the treatment of chronic cough with agents used for treating neuropathic pain such as gabapentin and amitryptiline would also support this concept. Research into neuropathic cough may lead to the discovery of more effective antitussives.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.