Evidence map›Paper›PMID 25383163›Full record

ArticleChemical science2014

Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species.

Alaina S DeToma, Janarthanan Krishnamoorthy, Younwoo Nam, Hyuck Jin Lee, Jeffrey R Brender, Akiko Kochi, Dongkuk Lee, Valentina Onnis, Cenzo Congiu, Stefano Manfredini and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

Alaina S DeTomaDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
Janarthanan KrishnamoorthyDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA ; Biophysics, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
Younwoo NamLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA ; Department of Fine Chemistry, Seoul National University of Science and Technology, Seoul, Korea ; Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea.
Hyuck Jin LeeDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA ; Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea.
Jeffrey R BrenderDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA ; Biophysics, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
Akiko KochiDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA ; Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea.
Dongkuk LeeDepartment of Fine Chemistry, Seoul National University of Science and Technology, Seoul, Korea.
Valentina OnnisDepartment of Life Sciences and Biotechnology, University of Ferrara, I-44121 Ferrara, Italy.
Cenzo CongiuDepartment of Life Sciences and Biotechnology, University of Ferrara, I-44121 Ferrara, Italy.
Stefano ManfrediniDepartment of Life and Environment Sciences, Pharmaceutical, Pharmacological and Nutraceutical Sciences Unit, University of Cagliari, I-09124 Cagliari, Italy.
Silvia VertuaniDepartment of Life and Environment Sciences, Pharmaceutical, Pharmacological and Nutraceutical Sciences Unit, University of Cagliari, I-09124 Cagliari, Italy.
Gianfranco BalboniDepartment of Life Sciences and Biotechnology, University of Ferrara, I-44121 Ferrara, Italy.
Ayyalusamy RamamoorthyDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, USA ; Biophysics, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
Mi Hee LimLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA ; Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea.
University of Michigan–Ann Arbor · USPharmac · NZUniversity of Ferrara · ITSeoul National University of Science and Technology · KRUlsan National Institute of Science and Technology · KRUniversity of Cagliari · IT

Funding

Supplement: Investigation of Membrane-Bound Cytochromes-P450-b5 InteractionsR01GM084018 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAMAMOORTHY, AYYALUSAMY · 2009 to 2018
$3.8M
NIGMS NIH HHS R01 GM084018
6 · The paper itself

Abstract

Metal ion homeostasis in conjunction with amyloid-β (Aβ) aggregation in the brain has been implicated in Alzheimer's disease (AD) pathogenesis. To uncover the interplay between metal ions and Aβ peptides, synthetic, multifunctional small molecules have been employed to modulate Aβ aggregation

Identifiers

PMID25383163
PMCPMC4217218
OpenAlexW2100846798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.