Evidence map›Paper›PMID 25382978›Full record

ArticleNeuropsychiatric disease and treatment2014

Magnetic seizure therapy in an adolescent with refractory bipolar depression: a case report.

Yoshihiro Noda, Zafiris J Daskalakis, Jonathan Downar, Paul E Croarkin, Paul B Fitzgerald, Daniel M Blumberger

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Magnetic seizure therapy for people with schizophrenia.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Guideline
  3. Trial
  4. Article
  5. Review
  6. Review
  7. An overview on clinical aspects in magnetic seizure therapy.Journal of neural transmission (Vienna, Austria : 1996) · 2016
    Review
  8. Pediatric Neuromodulation Comes of Age.Journal of child and adolescent psychopharmacology · 2016
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yoshihiro NodaDepartment of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada ; Temerty Centre for Therapeutic Brain Intervention, Toronto, ON, Canada.
Zafiris J DaskalakisDepartment of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada ; Temerty Centre for Therapeutic Brain Intervention, Toronto, ON, Canada ; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Jonathan DownarMRI-Guided rTMS Clinic, University Health Network, Toronto, ON, Canada.
Paul E CroarkinDivision of Child and Adolescent Psychiatry, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Paul B FitzgeraldMonash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne, Australia.
Daniel M BlumbergerDepartment of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada ; Temerty Centre for Therapeutic Brain Intervention, Toronto, ON, Canada ; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Funding

Glutamate Probes in Adolescent DepressionK23MH100266 · NIMH · MAYO CLINIC ROCHESTER · PI CROARKIN, PAUL E · 2014 to 2017
$685k
NIMH NIH HHS K23 MH100266
6 · The paper itself

Abstract

Magnetic seizure therapy (MST) has shown efficacy in adult patients with treatment-resistant depression with limited impairment in memory. To date, the use of MST in adolescent depression has not been reported. Here we describe the first successful use of MST in the treatment of an adolescent patient with refractory bipolar depression. This patient received MST in an ongoing open-label study for treatment-resistant major depression. Treatments employed a twin-coil MST apparatus, with the center of each coil placed over the frontal cortex (ie, each coil centered over F3 and F4). MST was applied at 100 Hz and 100% machine output at progressively increasing train durations. Depressive symptoms were assessed using the 24-item Hamilton Depression Rating Scale and cognitive function was assessed with a comprehensive neuropsychological battery. This adolescent patient achieved full remission of clinical symptoms after an acute course of 18 MST treatments and had no apparent cognitive decline, other than some autobiographical memory impairment that may or may not be related to the MST treatment. This case report suggests that MST may be a safe and well tolerated intervention for adolescents with treatment-resistant bipolar depression. Pilot studies to further evaluate the effectiveness and safety of MST in adolescents warrant consideration.

Indexed as

adolescent depressionbrain stimulationcognitive effectstreatment-resistant depression

Identifiers

PMID25382978
PMCPMC4222618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.