Evidence map›Paper›PMID 25382872›Full record

ArticleMolecular biology2012

Regulation of

Tanja Francetic, Melanie Le May, Munerah Hamed, Hymn Mach, David Meyers, Philip A Cole, Jihong Chen, Qiao Li

Open access · hybridAbstract read
In one paragraph

Article in Molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Exploring the Regulation ofJournal of developmental biology · 2025
    Article
  4. Tissue-Specific Expression of the PorcineAnimals : an open access journal from MDPI · 2025
    Article
  5. Signal pathways and precision therapy of small-cell lung cancer.Signal transduction and targeted therapy · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tanja FranceticCellular and Molecular, Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON Canada.
Melanie Le MayCellular and Molecular, Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON Canada.
Munerah HamedCellular and Molecular, Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON Canada.
Hymn MachDepartments of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON Canada.
David MeyersDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD USA.
Philip A ColeDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD USA.
Jihong ChenDepartments of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON Canada.
Qiao LiDepartments of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON Canada ; Cellular and Molecular, Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON Canada.
University of Ottawa · CA

Funding

Protein Acylation and Methylation Mechanisms_Administrative SupplementR37GM062437 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COLE, PHILIP A · 2013 to 2022
$4.1M
Mechanisms &Inhibition of Histone AcetyltransferasesR01GM062437 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COLE, PHILIP A · 2001 to 2012
$3.8M
NIGMS NIH HHS R01 GM062437NIGMS NIH HHS R37 GM062437
6 · The paper itself

Abstract

Skeletal myogenesis is an intricate process coordinated temporally by multiple myogenic regulatory factors (MRF) including Myf5, which is the first MRF expressed and marks the commitment of skeletal muscle lineage. The expression of Myf5 gene during early embryogenesis is controlled by a set of enhancer elements, and requires the histone acetyltransferase (HAT) activity of transcriptional coactivator p300. However, it is unclear as to how different regulatory signals converge at enhancer elements to regulate early Myf5 gene expression, and if p300 is directly involved. We show here that p300 associates with the

Indexed as

AcetyltransferaseGene regulationHistone acetylationRegulatory elementsStem cell differentiationTranscription factor

Identifiers

PMID25382872
PMCPMC4222083
OpenAlexW2119558650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.