ArticleJournal of applied toxicology : JAT2015
Tributyltin alters secretion of interleukin 1 beta from human immune cells.
Article in Journal of applied toxicology : JAT, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Maternal tributyltin exposure is associated with male-biased immune dysregulation across generations.Endocrinology · 2026Article
- The ENDOMIX perspective: how everyday chemical mixtures impact human health and reproduction by targeting the immune system†.Biology of reproduction · 2024Review
- Interleukin 1β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan.Archives of toxicology · 2024Article
- Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin.Toxics · 2023Review
- Role of microRNA in Endocrine Disruptor-Induced Immunomodulation of Metabolic Health.Metabolites · 2022Review
- Toll-like receptors in the mechanism of tributyltin-induced production of pro-inflammatory cytokines, IL-1β and IL-6.Toxicology · 2022Article
- Review
- Tributyltin Oxide Exposure DuringFrontiers in cell and developmental biology · 2021Article
- Endocrine Disruptor Compounds-A Cause of Impaired Immune Tolerance Driving Inflammatory Disorders of Pregnancy?Frontiers in endocrinology · 2021Review
- Exposures to the environmental contaminants pentachlorophenol and dichlorodiphenyltrichloroethane increase production of the proinflammatory cytokine, interleukin-1β, in human immune cells.Journal of applied toxicology : JAT · 2019Article
- Synthesis of interleukin 1 beta and interleukin 6 in human lymphocytes is stimulated by tributyltin.Archives of toxicology · 2018Article
- Tributyltin stimulates synthesis of interferon gamma and tumor necrosis factor alpha in human lymphocytes.Journal of applied toxicology : JAT · 2018Article
- Butyltin compounds alter secretion of interleukin 6 from human immune cells.Journal of applied toxicology : JAT · 2018Article
- Tributyltin and Zebrafish: Swimming in Dangerous Water.Frontiers in endocrinology · 2018Review
- Dibutyltin-induced alterations of interleukin 1beta secretion from human immune cells.Journal of applied toxicology : JAT · 2017Article
- The effect of Tributyltin on thyroid follicular cells of adult male albino rats and the possible protective role of green tea: a toxicological, histological and biochemical study.Egyptian journal of forensic sciences · 2017Article
- Tributyltin exposure alters cytokine levels in mouse serum.Journal of immunotoxicology · 2016Article
- Hexabromocyclododecane and tetrabromobisphenol A alter secretion of interferon gamma (IFN-γ) from human immune cells.Archives of toxicology · 2016Article
- Tetrabromobisphenol A and hexabromocyclododecane alter secretion of IL-1β from human immune cells.Journal of immunotoxicology · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tributyltin (TBT) has been used as a biocide in industrial applications such as wood preservation, antifouling paint and antifungal agents. Owing to its many uses, it contaminates the environment and has been found in human blood samples. Interleukin-1 beta (IL-1β) is a pro-inflammatory cytokine that promotes cell growth, tissue repair and immune response regulation. Produced predominately by both monocytes and macrophages, IL-1β appears to increase the invasiveness of certain tumors. This study shows that TBT modifies the secretion of IL-1β from increasingly reconstituted preparations of human immune cells. IL-1β secretion was examined after 24-, 48-h or 6-day exposures to TBT in highly enriched human natural killer (NK) cells, monocyte-depleted peripheral blood mononuclear cells (MD-PBMCs), PBMCs, granulocytes and a preparation combining both PBMCs and granulocytes (PBMCs+granulocytes). TBT altered IL-1β secretion from all of the cell preparations. The 200 nM concentration of TBT normally blocked the secretion of IL-1β, whereas lower concentrations (usually 5-50 nM) elevated secretion of IL-1β. Examination of the signaling pathway(s) responsible for the elevated secretion of IL-1β was carried out in MD-PBMCs. Pathways examined were IL-1β processing (Caspase-1), mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NFκB). Results indicated that MAPK pathways (p44/42 and p38) appear to be the targets of TBT that lead to increased IL-1β secretion from immune cells. These results from human immune cells show IL-1β dysregulation by TBT is occurring ex vivo. Thus, the potential for in vivo effects on pro-inflammatory cytokine levels may possibly be a consequence of TBT exposures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.