Evidence map›Paper›PMID 25382561›Full record

SynthesisThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2015

Fetal growth and maternal glomerular filtration rate: a systematic review.

Hanna M Vesterinen, Paula I Johnson, Dylan S Atchley, Patrice Sutton, Juleen Lam, Marya G Zlatnik, Saunak Sen, Tracey J Woodruff

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 9 pooled it
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 9 syntheses or guidelines pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hanna M Vesterinena Department of Obstetrics , Gynecology, and Reproductive Sciences, UCSF Program on Reproductive Health and the Environment, University of California , San Francisco , CA , USA .
Paula I Johnsona Department of Obstetrics , Gynecology, and Reproductive Sciences, UCSF Program on Reproductive Health and the Environment, University of California , San Francisco , CA , USA .
Dylan S Atchleya Department of Obstetrics , Gynecology, and Reproductive Sciences, UCSF Program on Reproductive Health and the Environment, University of California , San Francisco , CA , USA .
Patrice Suttona Department of Obstetrics , Gynecology, and Reproductive Sciences, UCSF Program on Reproductive Health and the Environment, University of California , San Francisco , CA , USA .
Juleen Lamc Department of Health , Policy and Management, John Hopkins University , Baltimore , MD , USA .
Marya G Zlatnikd Department of Obstetrics , Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine, UCSF , San Francisco , CA , USA , and.
Saunak Sene Department of Epidemiology and Biostatistics , UCSF , San Francisco , CA , USA.
Tracey J Woodruffa Department of Obstetrics , Gynecology, and Reproductive Sciences, UCSF Program on Reproductive Health and the Environment, University of California , San Francisco , CA , USA .
University of California, San Francisco · USJohns Hopkins University · US

Funding

The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's CenterP01ES022841 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, TRACEY J. · 2013 to 2018
$3.9M
NIEHS NIH HHS P01 ES022841
6 · The paper itself

Abstract

objectiveGlomerular filtration rate (GFR) may influence concentrations of biomarkers of exposure and their etiologic significance in observational studies of associations between environmental contaminants and fetal growth. It is unknown whether the size of a developing fetus affects maternal GFR such that a small fetus leads to reduced plasma volume expansion (PVE), reduced GFR and subsequent higher concentrations of biomarkers in maternal serum. Our objective was to answer the question: "Is there an association between fetal growth and maternal GFR in humans?"

methodsWe adapted and applied the Navigation Guide systematic review methodology to assess the evidence of an association between fetal growth and GFR, either directly or indirectly via reduction in PVE.

resultsWe identified 35 relevant studies. We rated 31 human and two non-human observational studies as "low" quality and two experimental non-human studies as "very low" quality. We rated all three evidence streams as "inadequate". The association between fetal growth and GFR was "not classifiable" according to pre-specified definitions.

conclusionsThere is currently insufficient evidence to support the plausibility of a reverse causality hypothesis for associations between exposure to environmental chemicals during pregnancy and fetal growth. Further research would be needed to confirm or disprove this hypothesis.

Indexed as

FemaleFetal DevelopmentGlomerular Filtration RateHumansPregnancyFetal growthglomerular filtration rateperfluorooctanoic acidplasma volume expansionreproductive environmental healthreverse causalitythe navigation guide

Identifiers

PMID25382561
PMCPMC6688630
OpenAlexW2134700529

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.