ArticleCell and tissue research1989
Distribution and frequency of neuro-epithelial bodies in post-natal rabbit lung: quantitative study with monoclonal antibody against serotonin.
Article in Cell and tissue research, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 86 citations in OpenAlex.
- Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction.Developmental cell · 2022Article
- Non-neuronal cholinergic system in airways and lung cancer susceptibility.Translational lung cancer research · 2013Review
- NADPH oxidase is an O2 sensor in airway chemoreceptors: evidence from K+ current modulation in wild-type and oxidase-deficient mice.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Immunohistochemical distribution of bombesin-positive pulmonary neuroendocrine cells in a congenital diaphragmatic hernia.Surgery today · 1999Article
- Mapping the distribution of neuroepithelial bodies of the rat lung. A whole-mount immunohistochemical approach.The American journal of pathology · 1997Article
- NADPH-oxidase and a hydrogen peroxide-sensitive K+ channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Adrenoceptor- and cholinoceptor-mediated mechanisms in the regulation of 5-hydroxytryptamine release from isolated tracheae of newborn rabbits.British journal of pharmacology · 1996Article
- Pulmonary Neuroendocrine Cells and Lung Development.Endocrine pathology · 1996Article
- Characterization of 5-hydroxytryptamine release from isolated rabbit and rat trachea: the role of neuroendocrine epithelia cells and mast cells.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Association of immune cells with neuroepithelial bodies in the lungs of neonatal dogs, cats and hamsters.Cell and tissue research · 1995Article
- Hamster pulmonary endocrine cells with neural cell adhesion molecule (NCAM) immunostaining.Histochemistry and cell biology · 1995Article
- Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching morphogenesis via a receptor-mediated mechanism.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Article
- Neuroepithelial bodies in the Fawn Hooded rat lung: morphological and neuroanatomical evidence for a sensory innervation.Journal of anatomy · 1993Article
- Immunohistochemical colocalization of 7B2 and 5HT in the neuroepithelial bodies of the lung of Rana temporaria.Cell and tissue research · 1993Article
- Evidence for the coexistence of serotonin and calcitonin gene-related peptide at the subcellular level in neuroepithelial bodies in the lung of a marsupial, Isoodon macrourus.Cell and tissue research · 1992Article
- Article
- Diethylnitrosamine-induced pulmonary endocrine cell hyperplasia and its association with adenomatosis and adenocarcinoma in rabbits.The American journal of pathology · 1989Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution, frequency and size of neuroepithelial bodies (NEB) were studied in lungs of rabbits during different stages of development (27-day fetus, newborn, 6, 11, 21, 28 and 56 days postnatally). NEB were visualized by immunostaining with monoclonal antibody against serotonin. Detailed quantitation of NEB was performed by use of camera lucida drawings of immunostained serial sections from the same anatomical region, i.e. the lower lobe of the left lung. The total number of NEB was counted and expressed per epithelial length of airway, surface area and volume. The size of NEB defined as surface area as well as the position of NEB in relation to the airway bifurcations was assessed in airways of different sizes. The overall number and size of NEB were found to increase during the immediate perinatal period followed by a sharp decline at 56 days of age. The number of NEB peaked at 6 days postnatally (mean 175.5 NEB/mm3 of airway epithelium) and declined significantly (3.0 NEB/mm3) at 56 days of postnatal age. The size of NEB reached its maximum at 11 days (mean surface area 659.54 microns 2, with the largest NEB measuring 1839.98 microns 2). By 56 days of age, NEB became significantly smaller (mean surface area 177.29 microns 2) consisting of small clusters of cells situated deep within the airway epithelium. At all ages, about half of all NEB (mean 47.6%) were localized within the small peripheral airways with up to 63.9% located at airway bifurcations. These findings indicate that the "functional activity" of NEB may be confined predominantly to the perinatal period. The postulated functions of NEB include those of intrapulmonary hypoxia-sensitive chemoreceptors and/or endocrine-paracrine activity in the lung. Such functions(s) may be important during adaptation to extrauterine life as well as for growth and development of the lung.
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