ArticleCell and tissue research1989
Outer segment growth and periciliary vesicle turnover in developing photoreceptors of Xenopus laevis.
Article in Cell and tissue research, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Cone outer segments: a biophysical model of membrane dynamics, shape retention, and lamella formation.Biophysical journal · 2012Article
- Distal invaginations and the renewal of cone outer segments in anuran and monkey retinas.Cell and tissue research · 1990Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been proposed that periciliary vesicles in the photoreceptor inner segment represent newly synthesized membrane en route to the outer segment, and that membrane is delivered to the outer segment via fusion of these vesicles with the plasma membrane at the base of the connecting cilium and sclerad flow of the ciliary membrane. The present research was undertaken to test the periciliary vesicle hypothesis and clarify the dynamics of membrane flow in vertebrate photoreceptors. Light- and electron-microscopic measurements on developing photoreceptors in the retina of Xenopus laevis were used to determine the amount of membrane in outer segments and in periciliary vesicles. No significant diurnal variations were found in outer segment growth rate or size of the periciliary vesicle population. In all rods and in cones at the end of the experiment, the area of periciliary vesicle membrane was proportional to the rate at which membrane was added to the outer segment. Thus, the turnover time for the periciliary vesicle population was similar in rods and cones, supporting the periciliary vesicle hypothesis. Quantification of periciliary vesicle membrane in inner segments provides a method for determining the rate at which membrane is added to outer segments, heretofore not possible for cones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.