ArticleAnnals of neurology2015
Retinal damage and vision loss in African American multiple sclerosis patients.
Article in Annals of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Retinal ganglion cell analysis in multiple sclerosis and optic neuritis: a systematic review and meta-analysis.Journal of neurology · 2017Pooled it
- Review
- Individual Prognostication of Disease Activity and Disability Worsening in Multiple Sclerosis With Retinal Layer ThicknessNeurology(R) neuroimmunology & neuroinflammation · 2024Article
- A comparison of multiple sclerosis disease characteristics across three genetically diverse Asian racial groups in Singapore.Scientific reports · 2024Observational
- Modifiable risk factors for multiple sclerosis have consistent directions of effect across diverse ethnic backgrounds: a nested case-control study in an English population-based cohort.Journal of neurology · 2024Article
- Predictors of Long-Term Visual Acuity in a Modern Cohort of Patients With Acute Idiopathic and Multiple Sclerosis-Associated Optic Neuritis.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2023Observational
- Health Disparities in Multiple Sclerosis among Hispanic and Black Populations in the United States.Biomedicines · 2023Review
- A narrative review of neuro-ophthalmologic disease in African Americans and Hispanics with multiple sclerosis.Therapeutic advances in chronic disease · 2023Review
- Understanding humoral immunity and multiple sclerosis severity in Black, and Latinx patients.Frontiers in immunology · 2023Review
- Towards a global view of multiple sclerosis genetics.Nature reviews. Neurology · 2022Review
- Racial disparities in hypertension management among multiple sclerosis patients.Multiple sclerosis and related disorders · 2022Article
- Leveraging Visual Outcome Measures to Advance Therapy Development in Neuroimmunologic Disorders.Neurology(R) neuroimmunology & neuroinflammation · 2022Review
- Article
- Socioeconomic disparity is associated with faster retinal neurodegeneration in multiple sclerosis.Brain : a journal of neurology · 2021Article
- Optical coherence tomography in multiple sclerosis: A 3-year prospective multicenter study.Annals of clinical and translational neurology · 2021Observational
- Evidence of subclinical quantitative retinal layer abnormalities in AQP4-IgG seropositive NMOSD.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Effect of Obesity on Retinal Integrity in African Americans and Caucasian Americans With Relapsing Multiple Sclerosis.Frontiers in neurology · 2021Article
- Eye Examination Recency among African American Older Adults with Chronic Medical Conditions.Healthcare (Basel, Switzerland) · 2020Article
- Race and ethnicity on MS presentation and disease course.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Review
- Using Acute Optic Neuritis Trials to Assess Neuroprotective and Remyelinating Therapies in Multiple Sclerosis.JAMA neurology · 2020Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether African American (AA) multiple sclerosis (MS) patients exhibit more retinal damage and visual impairment compared to Caucasian American (CA) MS patients.
methodsA total of 687 MS patients (81 AAs) and 110 healthy control (HC) subjects (14 AAs) were recruited at 3 academic hospitals between 2008 and 2012. Using mixed effects regression models, we compared high- and low-contrast visual acuity (HCVA and LCVA) and high-definition spectral domain optical coherence tomography measures of retinal architecture between MS patients of self-identified AA and CA ancestry.
resultsIn HCs, baseline peripapillary retinal nerve fiber layer (RNFL) thickness was 6.1µm greater in AAs (p = 0.047), whereas ganglion cell/inner plexiform layer (GCIP) thickness did not differ by race. In MS patients, baseline RNFL did not differ by race, and GCIP was 3.98µm thinner in AAs (p = 0.004). AAs had faster RNFL and GCIP thinning rates compared to CAs (p = 0.004 and p = 0.046, respectively). AA MS patients had lower baseline HCVA (p = 0.02) and worse LCVA per year of disease duration (p = 0.039). Among patients with an acute optic neuritis (AON) history, AAs had greater loss of HCVA than CA patients (p = 0.012).
interpretationThis multicenter investigation provides objective evidence that AA MS patients exhibit accelerated retinal damage compared to CA MS patients. Self-identified AA ancestry is associated with worse MS-related visual disability, particularly in the context of an AON history, suggesting a more aggressive inflammatory disease course among AA MS patients or a subpopulation therein.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.