ArticleNature communications2014
High-resolution structure and mechanism of an F/V-hybrid rotor ring in a Na⁺-coupled ATP synthase.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 82 citations in OpenAlex.
- Methanol Metabolism in the Cytochrome and Menaquinone-Containing Acetogen Moorella thermoacetica.Environmental microbiology · 2026Article
- Secondary metabolites fromRSC advances · 2026Article
- Structure of ATP synthase from an early photosynthetic bacteriumProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Redirecting electron flow in Acetobacterium woodii enables growth on CO and improves growth on formate.Nature communications · 2024Article
- A new metabolic trait in an acetogen: Mixed acid fermentation of fructose in a methylene-tetrahydrofolate reductase mutant of Acetobacterium woodii.Environmental microbiology reports · 2023Article
- Lactate formation from fructose or C1 compounds in the acetogen Acetobacterium woodii by metabolic engineering.Applied microbiology and biotechnology · 2023Article
- Reprogramming the metabolism of an acetogenic bacterium to homoformatogenesis.The ISME journal · 2023Article
- Direct observation of stepping rotation of V-ATPase reveals rigid component in coupling between VProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Biosynthesis of butyrate from methanol and carbon monoxide by recombinant Acetobacterium woodii.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- ATP synthesis in an ancient ATP synthase at low driving forces.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- ATP synthase FCellular and molecular life sciences : CMLS · 2022Review
- Systems Biology on Acetogenic Bacteria for Utilizing C1 Feedstocks.Advances in biochemical engineering/biotechnology · 2022Article
- Engineering Acetogenic Bacteria for Efficient One-Carbon Utilization.Frontiers in microbiology · 2022Review
- Energy Conservation in the Acetogenic BacteriumMicroorganisms · 2021Article
- Overcoming Energetic Barriers in Acetogenic C1 Conversion.Frontiers in bioengineering and biotechnology · 2020Review
- Essential ion binding residues for NaScientific reports · 2019Article
- Structural Asymmetry and Kinetic Limping of Single Rotary F-ATP Synthases.Molecules (Basel, Switzerland) · 2019Review
- Genome-scale analysis ofRNA (New York, N.Y.) · 2018Article
- The Rnf Complex Is an Energy-Coupled Transhydrogenase Essential To Reversibly Link Cellular NADH and Ferredoxin Pools in the Acetogen Acetobacterium woodii.Journal of bacteriology · 2018Article
- Membrane plasticity facilitates recognition of the inhibitor oligomycin by the mitochondrial ATP synthase rotor.Biochimica et biophysica acta. Bioenergetics · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
All rotary ATPases catalyse the interconversion of ATP and ADP-Pi through a mechanism that is coupled to the transmembrane flow of H(+) or Na(+). Physiologically, however, F/A-type enzymes specialize in ATP synthesis driven by downhill ion diffusion, while eukaryotic V-type ATPases function as ion pumps. To begin to rationalize the molecular basis for this functional differentiation, we solved the crystal structure of the Na(+)-driven membrane rotor of the Acetobacterium woodii ATP synthase, at 2.1 Å resolution. Unlike known structures, this rotor ring is a 9:1 heteromer of F- and V-type c-subunits and therefore features a hybrid configuration of ion-binding sites along its circumference. Molecular and kinetic simulations are used to dissect the mechanisms of Na(+) recognition and rotation of this c-ring, and to explain the functional implications of the V-type c-subunit. These structural and mechanistic insights indicate an evolutionary path between synthases and pumps involving adaptations in the rotor ring.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.