ArticleMedical microbiology and immunology2015
Streptolysin S of Streptococcus anginosus exhibits broad-range hemolytic activity.
Article in Medical microbiology and immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- From commensal to pathogen: recent advances in the pathogenicity and clinical implications ofFrontiers in microbiology · 2026Review
- Mitigating Virulence of Environmental Enterococcus faecalis Via Fermented Food-Derived Lactic Acid Bacteria.Current microbiology · 2025Article
- Streptococcus anginosus: the potential role in the progression of gastric cancer.Journal of cancer research and clinical oncology · 2025Review
- Genomic and transcriptomic insights into the virulence and adaptation of shock syndrome-causingMicrobiology (Reading, England) · 2025Article
- Oral streptococciInfection and immunity · 2024Article
- Role of the gut microbiota in tumorigenesis and treatment.Theranostics · 2024Review
- Streptolysin S induces pronounced calcium-ion influx-dependent expression of immediate early genes encoding transcription factors.Scientific reports · 2023Article
- Studies of Streptococcus anginosus Virulence in Dictyostelium discoideum and Galleria mellonella Models.Infection and immunity · 2023Article
- Virulence factors ofFrontiers in microbiology · 2022Review
- Incidence and Clinical Outcomes of Streptococcus anginosus in Acute Complicated Sinusitis: A Pediatric Cohort.Journal of the Pediatric Infectious Diseases Society · 2021Article
- Effect of Streptococcus anginosus on biological response of tongue squamous cell carcinoma cells.BMC oral health · 2021Article
- Characterization of Esophageal Microbiota in Patients With Esophagitis and Esophageal Squamous Cell Carcinoma.Frontiers in cellular and infection microbiology · 2021Article
- Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort.Open forum infectious diseases · 2020Article
- Prevalence of Antimicrobial Resistance and Hemolytic Phenotypes in Culturable Arctic Bacteria.Frontiers in microbiology · 2020Article
- Selectived and Reshaped Early Dominant Microbial Community in the Cecum With Similar Proportions and Better Homogenization and Species Diversity Due to Organic Acids as AGP Alternatives Mediate Their Effects on Broilers Growth.Frontiers in microbiology · 2019Article
- The Pathogenesis OfInfection and drug resistance · 2019Article
- β-HemolyticJournal of oral microbiology · 2019Article
- Regulation of the β-hemolysin gene cluster of Streptococcus anginosus by CcpA.Scientific reports · 2018Article
- Human Oral Buccal Microbiomes Are Associated with Farmworker Status and Azinphos-Methyl Agricultural Pesticide Exposure.Applied and environmental microbiology · 2017Article
- Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus anginosus is a commensal of mucous membranes and an emerging human pathogen. Some strains, including the type strain, display a prominent β-hemolytic phenotype. A gene cluster (sag), encoding a variant of streptolysin S (SLS) has recently been identified as the genetic background for β-hemolysin production in S. anginosus. In this study, we further characterized the hemolytic and cytolytic activity of the S. anginosus hemolysin in comparison with other streptococcal hemolysins. The results indicate that SLS of S. anginosus is a broad-range hemolysin able to lyse erythrocytes of different species, including horse, bovine, rabbit and even chicken. The hemolytic activity is temperature dependent, and a down-regulation of the hemolysin expression is induced in the presence of high glucose levels. Survival assays indicate that in contrast to other streptococcal species, S. anginosus does not require SLS for survival in the presence of human granulocytes. Cross-complementation studies using the sagB and sagD genes of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis demonstrated functional similarities to the S. anginosus SLS. Nevertheless, distinct differences to other streptolysin S variants were noted and provide further insights into the molecular mechanisms of SLS pathogen host interactions.
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