ArticleClinical & experimental metastasis2015
Bone metastases in gastrointestinal cancer.
Article in Clinical & experimental metastasis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- A pan-cancer single-cell transcriptomic atlas of human bone metastases.Cell reports. Medicine · 2026Article
- Bone metastasis in colorectal cancer: Pathophysiology, prognostic factors, survival outcomes, and treatment strategies - A comprehensive review.Journal of bone oncology · 2025Review
- Article
- Bone targeted nano-drug and nano-delivery.Bone research · 2024Review
- Distal Fibular Metastasis of Colorectal Carcinoma: A Case Report.Orthopedic reviews · 2024Article
- Prevalence and prognosis of bone metastases in common solid cancers at initial diagnosis: a population-based study.BMJ open · 2023Article
- Rectal carcinoma revealed by isolated mixed bone metastases.Clinical case reports · 2022Article
- Prognostic factors for bone metastases from head and neck squamous cell carcinoma: A case series of 97 patients.Molecular and clinical oncology · 2021Article
- Outcome of surgical treatment for bone metastases caused by colorectal cancer.Journal of gastrointestinal oncology · 2021Article
- Clinical features and KRAS mutation in colorectal cancer with bone metastasis.Scientific reports · 2020Article
- Nomogram to predict the risk and survival of synchronous bone metastasis in colorectal cancer: a population-based real-world analysis.International journal of colorectal disease · 2020Article
- Bone metastasis and skeletal-related events in patients with solid cancer: A Korean nationwide health insurance database study.PloS one · 2020Article
- Bone metastasis as primary presentation of pancreatic ductal adenocarcinoma: A case report and literature review.Clinical case reports · 2019Article
- Development of a novel model for predicting survival of patients with spine metastasis from colorectal cancer.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Article
- Patterns of bone metastases in newly diagnosed colorectal cancer: a real-world analysis in the SEER database.International journal of colorectal disease · 2019Article
- Systematic review: Incidence, risk factors, survival and treatment of bone metastases from colorectal cancer.Journal of bone oncology · 2018Review
- Observational
- Retrospective study of predictors of bone metastasis in colorectal cancer patients.Journal of bone oncology · 2017Article
- [Prognostic biomarkers for metastatic colorectal cancer].Der Pathologe · 2016Review
- Evaluation of epidemiological and pathological features of symptomatic spinal metastases in Romania - what could we learn from a retrospective study?Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal (CRC) and gastroesophageal (GEC) cancers unusually spread to the bone. However, bone metastases (BM) are responsible for skeletal-related events (SREs) associated with an altered quality of life. Aiming to describe the characteristics and prognostic influence of BM from gastro-intestinal cancers, we performed a retrospective analysis of prospectively collected data in patients treated in our institution (1996-2006). 189 patients (5.5 %) developed BM: 79 with GEC and 110 with CRC. 57 patients had bone-exclusive metastases. In univariate analyses, the median time to BM occurrence was correlated with the primary tumour (PT) localisation, surgery, histology and TNM staging. However, in multivariate analyses, the occurrence delay was significantly shorter only for patients with GEC (HR 2.1), N1-2 status (HR 1.9), M1 status (HR 2.4), and epidermoid carcinoma (HR 6.0). Pain was the most frequent clinical sign leading to BM diagnosis (77.2 %). SRE occurred in 55 % of patients. Median overall survivals (OSs) of patients with CRC and GEC were 9.4 months [95 % confidence interval (95 % CI) 6.4-11.1] and 3.4 months (95 % CI 2.5-9.0), respectively. In univariate analyses, OS was correlated with PT surgery and NM staging, and the number of BM. In multivariate analyses, only the PT surgery and the number of BM remained correlated with OS. Our results suggest that there may be a subset of patients associated with a quicker development of BM. Given their higher risk of SRE, they could benefit from an early screening, calling for further prospective studies encompassing patients with and without BM.
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