Evidence map›Paper›PMID 25381453›Full record

ArticleCarcinogenesis2015

Whole-miRNome profiling identifies prognostic serum miRNAs in esophageal adenocarcinoma: the influence of Helicobacter pylori infection status.

Rihong Zhai, Yongyue Wei, Li Su, Geoffrey Liu, Mathew H Kulke, John C Wain, David C Christiani

Registry-linked trialOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Carcinogenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02656589 (A Perspective Study of the Predictive Value of microRNA in Patients With HER2 Positive Advanced Stage Breast Cancer Who Were Treated With Herceptin), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02656589 unknown statusnot on this map

A Perspective Study of the Predictive Value of microRNA in Patients With HER2 Positive Advanced Stage Breast Cancer Who Were Treated With Herceptin

TypeobservationalSponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityRan2015 to 2018Enrolled300ConditionsBreast CancerArmsCapecitabine, Trastuzumab
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Serum Levels of 25-Hydroxyvitamin D at Diagnosis Are Not Associated with Overall Survival in Esophageal Adenocarcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Rihong ZhaiShenzhen Key Laboratory of Translational Medicine of Tumor, Shenzhen University School of Medicine, Shenzhen 518060, China, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA, Medical Oncology and Haematology, Department of Medicine, Princess Margaret Hospital, Toronto, Ontario M5G 2C4, Canada, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA and Department of Surgery and Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA rzhai@szu.edu.cn.
Yongyue WeiDepartment of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
Li SuDepartment of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
Geoffrey LiuMedical Oncology and Haematology, Department of Medicine, Princess Margaret Hospital, Toronto, Ontario M5G 2C4, Canada.
Mathew H KulkeDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA and.
John C WainDepartment of Surgery and.
David C ChristianiMedical Oncology and Haematology, Department of Medicine, Princess Margaret Hospital, Toronto, Ontario M5G 2C4, Canada, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Dana-Farber Cancer Institute · USShenzhen University · CN

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Marc G Weisskopf · 1985 to 2026
$44.6M
Translational studies of Hsp90 inhibitors in NSCLCP50CA090578 · NCI · DANA-FARBER CANCER INST · PI JOHNSON, BRUCE D · 2008 to 2012
$11.4M
Molecular and Genetic Analysis of Lung Cancer SurvivalR01CA092824 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 2002 to 2013
$5.9M
SPORE in Lung CancerP20CA090578 · NCI · DANA-FARBER CANCER INSTITUTE · PI JOHNSON, BRUCE E. · 2003 to 2007
$5.1M
GENETIC SUSCEPTIBILITY TO LUNG CANCERR01CA074386 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 1997 to 2008
$4.8M
Serum 25(OH)D levels, VDR and CYP24 polymorphisms, and NSCLC survivalR03CA119650 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WANG, ZHAOXI · 2006 to 2007
$162k
NCI NIH HHS CA119650NCI NIH HHS CA74386NCI NIH HHS CA90578NCI NIH HHS CA92824NCI NIH HHS P20 CA090578NCI NIH HHS P50 CA090578NCI NIH HHS R01 CA074386NCI NIH HHS R01 CA092824NCI NIH HHS R03 CA119650NIEHS NIH HHS ES000002NIEHS NIH HHS P30 ES000002
6 · The paper itself

Abstract

Cell free circulating microRNAs (cfmiRNAs) have been recognized as robust and stable biomarkers of cancers. However, little is known about the prognostic significance of cfmiRNAs in esophageal adenocarcinoma (EA). In this study, we explored whether specific cfmiRNA profiles could predict EA prognosis and whether Helicobacter pylori (HP) infection status could influence the association between cfmiRNAs and EA survival outcome. We profiled 1075 miRNAs in pooled serum samples from 30 EA patients and 30 healthy controls. The most relevant cfmiRNAs were then assessed for their associations with EA survival in an independent cohort of 82 patients, using Log-rank test and multivariate Cox regression models. Quantitative real-time PCR (qRT-PCR) was used for cfmiRNA profiling. HP infection status was determined by immunoblotting assay. We identified a panel of 18 cfmiRNAs that could distinguish EA patients from healthy subjects (P = 3.0E-12). In overall analysis and in HP-positive subtype patients, no cfmiRNA was significantly associated with EA prognosis. In HP-negative patients, however, 15 cfmiRNAs were significantly associated with overall survival (OS) (all P < 0.05). A combined 2-cfmiRNA (low miR-3935 and high miR-4286) risk score was constructed; that showed greater risk for worse OS (HR = 2.22, P = 0.0019) than individual cfmiRNA alone. Patients with high-risk score had >10-fold increased risk of death than patients with low risk score (P = 0.0302; HR = 10.91; P = 0.0094). Our findings suggest that dysregulated cfmiRNAs may contribute to EA survival outcome and HP infection status may modify the association between cfmiRNAs and EA survival.

Indexed as

Gene Expression ProfilingAdenocarcinomaAgedBiomarkers, TumorCase-Control StudiesEsophageal NeoplasmsFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHelicobacter InfectionsHelicobacter pyloriHumansMaleMicroRNAsMiddle AgedNeoplasm GradingBiomarkers, TumorMicroRNAs

Identifiers

PMID25381453
PMCPMC4291048
OpenAlexW2086817799

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.