ArticleThe Journal of infectious diseases2015
Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Probing Dermal Immunity to Mycobacteria through a Controlled Human Infection Model.ImmunoHorizons · 2024Trial
- BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination.Nature communications · 2024Article
- Comparative immune responses toiScience · 2023Article
- Blood transcriptional correlates of BCG-induced protection against tuberculosis in rhesus macaques.Cell reports. Medicine · 2023Article
- Using cross-species vaccination approaches to counter emerging infectious diseases.Nature reviews. Immunology · 2021Review
- Epidemiological transcriptomic data supports BCG protection in viral diseases including COVID-19.Gene · 2021Article
- A Systems Biology Workflow for Drug and Vaccine Repurposing: Identifying Small-Molecule BCG Mimics to Reduce or Prevent COVID-19 Mortality.Pharmaceutical research · 2020Article
- BCG Vaccinations Upregulate Myc, a Central Switch for Improved Glucose Metabolism in Diabetes.iScience · 2020Article
- Characterizing the BCG Induced Macrophage and Neutrophil Mechanisms for Defense AgainstFrontiers in immunology · 2020Article
- Tools for Assessing the Protective Efficacy of TB Vaccines in Humans:Frontiers in immunology · 2019Article
- Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin.Nature communications · 2018Article
- Detection of circulating Mycobacterium tuberculosis-specific DNA by droplet digital PCR for vaccine evaluation in challenged monkeys and TB diagnosis.Emerging microbes & infections · 2018Article
- The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays.Scientific reports · 2017Article
- Transcriptomics in Human Challenge Models.Frontiers in immunology · 2017Review
- What Have We Learnt about BCG Vaccination in the Last 20 Years?Frontiers in immunology · 2017Review
- Immunometabolic Pathways in BCG-Induced Trained Immunity.Cell reports · 2016Article
- A review of clinical models for the evaluation of human TB vaccines.Human vaccines & immunotherapeutics · 2016Review
- Activities of Murine Peripheral Blood Lymphocytes Provide Immune Correlates That Predict Francisella tularensis Vaccine Efficacy.Infection and immunity · 2016Article
- Tuberculosis.Lancet (London, England) · 2016Review
- Flow Cytometric Analysis of Protective T-Cell Response Against Pulmonary Coccidioides Infection.Methods in molecular biology (Clifton, N.J.) · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBacillus Calmette-Guerin (BCG) vaccine is the most widely administered vaccine in the world, yet its mechanism of action remains unclear. We hypothesize that certain immune pathways are associated with reduced mycobacterial growth following BCG challenge in human volunteers.
methodsWe used samples from a mycobacterial challenge in which previously BCG-vaccinated or BCG-naive adults in the United Kingdom were challenged intradermally with a standard dose of BCG. Any remaining BCG was quantified in a skin biopsy specimen obtained 2 weeks after challenge and used as a measure of BCG growth and functional antimycobacterial immunity. We measured the immune response over the 2-week challenge, using DNA microarrays and flow cytometry, and correlated this with mycobacterial growth.
resultsThe magnitude of the immune response to BCG is greater in previously vaccinated volunteers, and this correlates with reduced mycobacterial growth but increased scarring at the vaccination site. In particular, the interferon γ and interleukin 17 pathways are strongly induced in previously vaccinated volunteers and correlate with reduced mycobacterial growth in this population.
conclusionThis study identifies pathways associated with control of mycobacterial growth in vivo in human volunteers and supports the use of BCG challenge as a tool for evaluating vaccine efficacy and identifying mechanisms of antimycobacterial immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.