Evidence map›Paper›PMID 25381364›Full record

ReviewGenetics2014

Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae.

Lorraine S Symington, Rodney Rothstein, Michael Lisby

Open access · bronzeAbstract readReview
In one paragraph

Review in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 252 papers.

0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

252 citing papers in PubMed, 395 citations in OpenAlex.

  1. Article
  2. Detection of "hidden" mitotic crossovers by long-read DNA sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  9. HOP2-MND1 chaperones a diffusing DMC1-ssDNA complex to survey dsDNA for homology recognition during meiotic recombination.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Mutations and structural variants arising during double-strand break repair.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  11. Article
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  13. Asymmetrical recognition and processing of double-strand breaks formed during DNA replication.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  14. Article
  15. Article
  16. Article
  17. Structural basis for Rad54- and Hed1-mediated regulation of Rad51 during the transition from mitotic to meiotic recombination.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Article
  20. Article

192 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Lorraine S SymingtonDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, New York 10032.
Rodney RothsteinDepartment of Genetics and Development, Columbia University Medical Center, New York, New York 10032.
Michael LisbyDepartment of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Columbia University Irving Medical Center · USUniversity of Copenhagen · DK

Funding

The Role of CTIP in Lymphocyte Development and LymphomagenesisP01CA174653 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RABADAN, RAUL · 2014 to 2024
$17.6M
Mechanisms of Homologous Recombination in YeastR01GM041784 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SYMINGTON, LORRAINE S · 1989 to 2017
$7.8M
Mechanism of spontaneous and DSB-induced repairR37GM050237 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROTHSTEIN, RODNEY J. · 2005 to 2014
$6.0M
Genetics of the formation of repair &reombination fociR01GM067055 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROTHSTEIN, RODNEY J. · 2003 to 2014
$4.3M
MECHANISM OF SPONTANEOUS AND DSB-INDUCED REPAIRR01GM050237 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ROTHSTEIN, RODNEY J. · 1993 to 2016
$3.0M
Break-induced replication and genome rearrangementsR01GM094386 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SYMINGTON, LORRAINE S · 2010 to 2017
$2.4M
European Research Council 242905NCI NIH HHS P01 CA174653NIGMS NIH HHS GM41784NIGMS NIH HHS GM50237NIGMS NIH HHS GM67055NIGMS NIH HHS GM94386NIGMS NIH HHS R01 GM041784NIGMS NIH HHS R01 GM050237NIGMS NIH HHS R01 GM067055NIGMS NIH HHS R01 GM094386NIGMS NIH HHS R37 GM050237
6 · The paper itself

Abstract

Homology-dependent exchange of genetic information between DNA molecules has a profound impact on the maintenance of genome integrity by facilitating error-free DNA repair, replication, and chromosome segregation during cell division as well as programmed cell developmental events. This chapter will focus on homologous mitotic recombination in budding yeast Saccharomyces cerevisiae. However, there is an important link between mitotic and meiotic recombination (covered in the forthcoming chapter by Hunter et al. 2015) and many of the functions are evolutionarily conserved. Here we will discuss several models that have been proposed to explain the mechanism of mitotic recombination, the genes and proteins involved in various pathways, the genetic and physical assays used to discover and study these genes, and the roles of many of these proteins inside the cell.

Indexed as

Recombination, GeneticDNA DamageDNA, FungalGenetic TechniquesMitosisSaccharomyces cerevisiaeDNA, Fungalbudding yeastrecombinationrepair

Identifiers

PMID25381364
PMCPMC4224172
OpenAlexW1965593950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.