ArticleClinical journal of the American Society of Nephrology : CJASN2014
Urinary creatinine excretion, bioelectrical impedance analysis, and clinical outcomes in patients with CKD: the CRIC study.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lean tissue mass is associated with adverse outcomes across different stages of chronic kidney disease: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Associations of Creatinine Muscle Index with markers of sarcopenia and mortality in chronic kidney disease: A prospective cohort study.PLoS medicine · 2026Article
- Complex Etiologies of the Discordance Between Cystatin C- and Creatinine-Based Estimated GFR and Its Adverse Associations: Findings From the CRIC Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Article
- Variations in Creatinine Generation Among Patients With Glomerular Disease: Evidence From the NEPTUNE and CureGN Studies.Kidney medicine · 2025Article
- Obesity and Metabolic Health in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- Prognostic Value of Spot Urinary Creatinine Concentration and Its Relationship with Body Composition Parameters in HF Patients.Biomedicines · 2023Article
- Association between Urinary Creatinine Excretion and Hypothyroidism in Patients with Chronic Kidney Disease.Diagnostics (Basel, Switzerland) · 2023Article
- Association of the modified creatinine index with muscle strength and mortality in patients undergoing hemodialysis.Renal failure · 2022Article
- Population-Based Limits of Urine Creatinine Excretion.Kidney international reports · 2022Article
- Evaluation of nutritional status using bioelectrical impedance analysis in patients with inflammatory bowel disease.Intestinal research · 2022Article
- A Novel Application of Serum Creatinine and Cystatin C to Predict Sarcopenia in Advanced CKD.Frontiers in nutrition · 2022Article
- Nutritional and Non-Nutritional Predictors of Low Spot Urinary Creatinine Concentration in Patients with Heart Failure.Nutrients · 2021Article
- Chronic Dialysis Patients Are Depleted of Creatine: Review and Rationale for Intradialytic Creatine Supplementation.Nutrients · 2021Article
- The value of spot urinary creatinine as a marker of muscle wasting in patients with new-onset or worsening heart failure.Journal of cachexia, sarcopenia and muscle · 2021Article
- Systematic review and meta-analysis of lean mass and mortality: Rationale and study description.Osteoporosis and sarcopenia · 2021Article
- Slope of Kidney Function and Its Association with Longitudinal Mortality and Cardiovascular Disease among Individuals with CKD.Journal of the American Society of Nephrology : JASN · 2020Article
- Risk factors for decreased upper-limb muscle strength and its impact on survival in maintenance hemodialysis patients.International urology and nephrology · 2020Article
- The impact of kidney dysfunction categorized by urinary to serum creatinine ratio on clinical outcomes in patients with heart failure.Heart and vessels · 2020Observational
- Predictors of Net Acid Excretion in the Chronic Renal Insufficiency Cohort (CRIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Article
- Creatine is a Conditionally Essential Nutrient in Chronic Kidney Disease: A Hypothesis and Narrative Literature Review.Nutrients · 2019Review
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Abstract
BACKGROUND AND
objectivesPrevious studies in chronic disease states have demonstrated an association between lower urinary creatinine excretion (UCr) and increased mortality, a finding presumed to reflect the effect of low muscle mass on clinical outcomes. Little is known about the relationship between UCr and other measures of body composition in terms of the ability to predict outcomes of interest. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Using data from the Chronic Renal Insufficiency Cohort (CRIC), the relationship between UCr, fat free mass (FFM) as estimated by bioelectrical impedance analysis, and (in a subpopulation) whole-body dual-energy x-ray absorptiometry assessment of appendicular lean mass were characterized. The associations of UCr and FFM with mortality and ESRD were compared using Cox proportional hazards models.
resultsA total of 3604 CRIC participants (91% of the full CRIC cohort) with both a baseline UCr and FFM measurement were included; of these, 232 had contemporaneous dual-energy x-ray absorptiometry measurements. Participants were recruited between July 2003 and March 2007. UCr and FFM were modestly correlated (rho=0.50; P<0.001), while FFM and appendicular lean mass were highly correlated (rho=0.91; P<0.001). Higher urinary urea nitrogen, black race, younger age, and lower serum cystatin C level were all significantly associated with higher UCr. Over a median (interquartile range) of 4.2 (3.1-5.0) years of follow-up, 336 (9.3%) participants died and 510 (14.2%) reached ESRD. Lower UCr was associated with death and ESRD even after adjustment for FFM (adjusted hazard ratio for death per 1 SD higher level of UCr, 0.63 [95% confidence interval, 0.56 to 0.72]; adjusted hazard ratio for ESRD per 1 SD higher level of UCr, 0.70 [95% confidence interval, 0.63 to 0.75]).
conclusionsAmong a cohort of individuals with CKD, lower UCr is associated with death and ESRD independent of FFM as assessed by bioelectrical impedance analysis.
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