Evidence map›Paper›PMID 25381295›Full record

Observational studyNeurology2014

Vigabatrin retinal toxicity in children with infantile spasms: An observational cohort study.

Carol A Westall, Tom Wright, Filomeno Cortese, Ananthavalli Kumarappah, O Carter Snead, Joseph R Buncic

Erratum issuedOpen access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 86 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Ocular examinations, findings, and toxicity in children taking vigabatrin.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2022
    Article
  6. Article
  7. Review
  8. Medical treatment of tuberous sclerosis-related epilepsy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020
    Review
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Article
  18. Observational
  19. Treatment of infantile spasms.Epilepsia open · 2018
    Article
  20. Infantile Spasms-Have We Made Progress?Current neurology and neuroscience reports · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Carol A WestallFrom the Department of Ophthalmology and Vision Science (C.A.W., T.W., A.K., J.R.B.), and Faculty of Medicine (O.C.S.), The Hospital for Sick Children, University of Toronto (C.A.W., J.R.B., O.C.S.); and Hotchkiss Brain Institute, University of Calgary (F.C.), Canada. Carol.westall@sickkids.ca fcortese@ucalgary.ca.
Tom WrightFrom the Department of Ophthalmology and Vision Science (C.A.W., T.W., A.K., J.R.B.), and Faculty of Medicine (O.C.S.), The Hospital for Sick Children, University of Toronto (C.A.W., J.R.B., O.C.S.); and Hotchkiss Brain Institute, University of Calgary (F.C.), Canada.
Filomeno CorteseFrom the Department of Ophthalmology and Vision Science (C.A.W., T.W., A.K., J.R.B.), and Faculty of Medicine (O.C.S.), The Hospital for Sick Children, University of Toronto (C.A.W., J.R.B., O.C.S.); and Hotchkiss Brain Institute, University of Calgary (F.C.), Canada.
Ananthavalli KumarappahFrom the Department of Ophthalmology and Vision Science (C.A.W., T.W., A.K., J.R.B.), and Faculty of Medicine (O.C.S.), The Hospital for Sick Children, University of Toronto (C.A.W., J.R.B., O.C.S.); and Hotchkiss Brain Institute, University of Calgary (F.C.), Canada.
O Carter SneadFrom the Department of Ophthalmology and Vision Science (C.A.W., T.W., A.K., J.R.B.), and Faculty of Medicine (O.C.S.), The Hospital for Sick Children, University of Toronto (C.A.W., J.R.B., O.C.S.); and Hotchkiss Brain Institute, University of Calgary (F.C.), Canada.
Joseph R BuncicFrom the Department of Ophthalmology and Vision Science (C.A.W., T.W., A.K., J.R.B.), and Faculty of Medicine (O.C.S.), The Hospital for Sick Children, University of Toronto (C.A.W., J.R.B., O.C.S.); and Hotchkiss Brain Institute, University of Calgary (F.C.), Canada.
Allen Institute for Brain Science · US

Funding

Canadian Institutes of Health Research 51712-1
6 · The paper itself

Abstract

objectivesTo determine time to vigabatrin (VGB, Sabril; Lundbeck, Deerfield, IL) induced retinal damage in children with infantile spasms (IS) and to identify risk factors for VGB-induced retinal damage (VGB-RD).

methodsObservational cohort study including 146 participants (68 female, 81 male) with IS, an age-specific epilepsy syndrome of early infancy, treated with VGB. Participants ranged from 3 to 34.9 months of age (median 7.6 months). The median duration of VGB treatment was 16 months (range 4.6-78.5 months). Electroretinograms (ERGs) were performed according to the Standards of the International Society for Clinical Electrophysiology of Vision. Inclusion required baseline (pre-VGB or within 4 weeks of starting VGB treatment) and at least 2 follow-up ERGs. Significant reduction from baseline of the 30-Hz ERG flicker amplitude on 2 consecutive visits identified VGB-RD. Kaplan-Meier survival analyses depicted the effect of duration of VGB on VGB-RD.

resultsThese data represent the largest survival analysis of children treated with VGB who did not succumb to retinal toxicity during the study. Thirty of the 146 participants (21%) showed VGB-RD. The ERG amplitude reduced with duration of VGB treatment (p = 0.0004) with no recovery after VGB cessation. With 6 and 12 months of VGB treatment, 5.3% and 13.3%, respectively, developed VGB-RD. There was neither effect of age of initiation of VGB treatment nor sex of the child on survival statistics and no significant effect of cumulative dosage on the occurrence of VGB-RD.

conclusionsMinimizing VGB treatment to 6 months will reduce the prevalence of VGB-RD in patients with IS.

Indexed as

AnticonvulsantsChildChild, PreschoolCohort StudiesElectroretinographyFemaleFollow-Up StudiesHumansInfantKaplan-Meier EstimateMalePrevalenceRetinaRetinal DiseasesSpasms, InfantileTime FactorsAnticonvulsantsVigabatrin

Identifiers

PMID25381295
PMCPMC4277676
OpenAlexW2133572298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.