ArticleApplied and environmental microbiology2015
Transcriptomics-aided dissection of the intracellular and extracellular roles of microcystin in Microcystis aeruginosa PCC 7806.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
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- Metagenomic and Metatranscriptomic Insights into Population Diversity ofApplied and environmental microbiology · 2022Article
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- Diel Variations of Extracellular Microcystin Influence the Subcellular Dynamics of RubisCO inMicroorganisms · 2021Article
- Competitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena.Scientific reports · 2021Article
- Genome Mining and Evolutionary Analysis Reveal Diverse Type III Polyketide Synthase Pathways in Cyanobacteria.Genome biology and evolution · 2021Article
- Salt Shock Responses ofToxins · 2020Article
- A Review on the Study of Cyanotoxins in Paleolimnological Research: Current Knowledge and Future Needs.Toxins · 2019Review
- Programmed Cell Death-Like and Accompanying Release of Microcystin in Freshwater Bloom-Forming CyanobacteriumToxins · 2019Review
- Evaluating putative ecological drivers of microcystin spatiotemporal dynamics using metabarcoding and environmental data.Harmful algae · 2019Article
- Influence of cyanobacteria, mixotrophic flagellates, and virioplankton size fraction on transcription of microcystin synthesis genes in the toxic cyanobacterium Microcystis aeruginosa.MicrobiologyOpen · 2018Article
- Proteomic evidences for microcystin-RR-induced toxicological alterations in mice liver.Scientific reports · 2018Article
- Adaptation of the Freshwater Bloom-Forming CyanobacteriumFrontiers in microbiology · 2018Article
- Influence of temperature, mixing, and addition of microcystin-LR on microcystin gene expression in Microcystis aeruginosa.MicrobiologyOpen · 2017Article
- Contribution of theFrontiers in cellular and infection microbiology · 2017Article
- Microcystin-Bound Protein Patterns in Different Cultures of Microcystis aeruginosa and Field Samples.Toxins · 2016Article
- Microbial communities reflect temporal changes in cyanobacterial composition in a shallow ephemeral freshwater lake.The ISME journal · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have provided evidence for both intracellular and extracellular roles of the potent hepatotoxin microcystin (MC) in the bloom-forming cyanobacterium Microcystis. Here, we surveyed transcriptomes of the wild-type strain M. aeruginosa PCC 7806 and the microcystin-deficient ΔmcyB mutant under low light conditions with and without the addition of external MC of the LR variant (MC-LR). Transcriptomic data acquired by microarray and quantitative PCR revealed substantial differences in the relative expression of genes of the central intermediary metabolism, photosynthesis, and energy metabolism. In particular, the data provide evidence for a lower photosystem I (PSI)-to-photosystem II (PSII) ratio and a more pronounced carbon limitation in the microcystin-deficient mutant. Interestingly, only 6% of the transcriptional differences could be complemented by external microcystin-LR addition. This MC signaling effect was seen exclusively for genes of the secondary metabolism category. The orphan polyketide synthase gene cluster IPF38-51 was specifically downregulated in response to external MC-LR under low light. Our data suggest a hierarchical and light-dependent cross talk of secondary metabolites and support both an intracellular and an extracellular role of MC in Microcystis.
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