Evidence map›Paper›PMID 25381117›Full record

ArticleObesity surgery2015

Effects of Roux-en-Y gastric bypass surgery on visceral and subcutaneous fat density by computed tomography.

Martin Torriani, Adriana L Oliveira, Debora C Azevedo, Miriam A Bredella, Elaine W Yu

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Obesity surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02091323 (Effect of Modified Laparoscopic Roux-en-Y Gastric Bypass Surgery on Type 2 Diabetics With Lower Body Mass Index in China), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02091323 naunknown statusnot on this map

Effect of Modified Laparoscopic Roux-en-Y Gastric Bypass Surgery on Type 2 Diabetics With Lower Body Mass Index in China

TypeinterventionalSponsorGuangzhou General Hospital of Guangzhou Military CommandRan2014 to 2017Enrolled200ConditionsDiabetes Mellitus, Non-Insulin-DependentArmsgastric bypass surgery
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. GH administration decreases subcutaneous abdominal adipocyte size in men with abdominal obesity.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2017
    Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Impact of Bariatric Surgery on Adipose Tissue Biology.Journal of clinical medicine · 2021
    Review
  13. Article
  14. Article
  15. Does bariatric surgery improve adipose tissue function?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2016
    Review
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Martin TorrianiDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, YAW 6048, Boston, MA, 02114, USA, mtorriani@mgh.harvard.edu.
Adriana L Oliveira
Debora C Azevedo
Miriam A Bredella
Elaine W Yu
Massachusetts General Hospital · USHarvard University · US

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MARTIN TORRIANI · 1994 to 2026
$31.6M
Hormones/Genes in Women's Health: From Bench to BedsideK12HD051959 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M, REXRODE, KATHRYN M · 2005 to 2023
$8.8M
Skeletal health in obesity and after bariatric surgeryK23DK093713 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI YU, ELAINE WEI-YIN · 2012 to 2016
$788k
NCRR NIH HHS RR025758NCRR NIH HHS UL1 RR025758NICHD NIH HHS HD51959NICHD NIH HHS K12 HD051959NIDDK NIH HHS DK093713NIDDK NIH HHS K23 DK093713NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

We aimed to test the hypothesis that noninvasive fat density by computed tomography (CT) increases after Roux-en-Y gastric bypass (RYGB) and correlates with improved cardiometabolic risk. We examined 21 obese adults before and 12 months after RYGB and 16 obese nonsurgical controls followed for 12 months. Visceral (VAT) and subcutaneous adipose tissue (SAT) density increased after RYGB (P < 0.0001) while remaining stable in controls (P ≥ 0.1). In RYGB subjects, 12-month increase in VAT density correlated with decreased C-reactive protein (CRP) independent of change in VAT area or BMI (both P < 0.05). Twelve-month increase in SAT density correlated with increased HDL cholesterol independent of change in SAT area (P = 0.048), BMI (P = 0.03), or statin use (P = 0.002), and 1 unit increase in SAT density had increased odds of higher total abdominal fat loss (P = 0.002).

Indexed as

Gastric BypassTomography, X-Ray ComputedAbdominal FatAdultAgedBody CompositionCase-Control StudiesCholesterolCholesterol, HDLC-Reactive ProteinFemaleHumansIntra-Abdominal FatMaleMiddle AgedObesity, MorbidCholesterolCholesterol, HDLC-Reactive Protein

Identifiers

PMID25381117
PMCPMC4410853
OpenAlexW2086272572

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.