Evidence map›Paper›PMID 25381071›Full record

ArticleJournal of the American Board of Family Medicine : JABFM

Guidance for researchers developing and conducting clinical trials in practice-based research networks (PBRNs).

Rowena J Dolor, Kristine M Schmit, Deborah G Graham, Chester H Fox, Laura Mae Baldwin

Abstract read
In one paragraph

Article in Journal of the American Board of Family Medicine : JABFM. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Practice-Based Research Networks and Massage Therapy: a Scoping Review.International journal of therapeutic massage & bodywork · 2020
    Article
  5. Article
  6. Article
  7. A proposed approach to accelerate evidence generation for genomic-based technologies in the context of a learning health system.Genetics in medicine : official journal of the American College of Medical Genetics · 2018
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rowena J DolorFrom the Duke Clinical Research Institute, Duke University, Durham, NC (RJD); Department of Community and Family Medicine, Duke University Medical Center, Durham, NC (KMS); American Academy of Family Physicians National Research Network, Leawood, KS (DGG); DARTNet Institute, Wilmette, IL (DGG); Department of Family Medicine, University of Buffalo, Buffalo, NY (CHF); and the Department of Family Medicine, University of Washington, Seattle, WA (LMB). Rowena.dolor@duke.edu.
Kristine M SchmitFrom the Duke Clinical Research Institute, Duke University, Durham, NC (RJD); Department of Community and Family Medicine, Duke University Medical Center, Durham, NC (KMS); American Academy of Family Physicians National Research Network, Leawood, KS (DGG); DARTNet Institute, Wilmette, IL (DGG); Department of Family Medicine, University of Buffalo, Buffalo, NY (CHF); and the Department of Family Medicine, University of Washington, Seattle, WA (LMB).
Deborah G GrahamFrom the Duke Clinical Research Institute, Duke University, Durham, NC (RJD); Department of Community and Family Medicine, Duke University Medical Center, Durham, NC (KMS); American Academy of Family Physicians National Research Network, Leawood, KS (DGG); DARTNet Institute, Wilmette, IL (DGG); Department of Family Medicine, University of Buffalo, Buffalo, NY (CHF); and the Department of Family Medicine, University of Washington, Seattle, WA (LMB).
Chester H FoxFrom the Duke Clinical Research Institute, Duke University, Durham, NC (RJD); Department of Community and Family Medicine, Duke University Medical Center, Durham, NC (KMS); American Academy of Family Physicians National Research Network, Leawood, KS (DGG); DARTNet Institute, Wilmette, IL (DGG); Department of Family Medicine, University of Buffalo, Buffalo, NY (CHF); and the Department of Family Medicine, University of Washington, Seattle, WA (LMB).
Laura Mae BaldwinFrom the Duke Clinical Research Institute, Duke University, Durham, NC (RJD); Department of Community and Family Medicine, Duke University Medical Center, Durham, NC (KMS); American Academy of Family Physicians National Research Network, Leawood, KS (DGG); DARTNet Institute, Wilmette, IL (DGG); Department of Family Medicine, University of Buffalo, Buffalo, NY (CHF); and the Department of Family Medicine, University of Washington, Seattle, WA (LMB).

Funding

Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1TR000423NCATS NIH HHS UL1 TR001117NCATS NIH HHS UL1TR001117
6 · The paper itself

Abstract

backgroundThere is increased interest nationally in multicenter clinical trials to answer questions about clinical effectiveness, comparative effectiveness, and safety in real-world community settings. Primary care practice-based research networks (PBRNs), comprising community- and/or academically affiliated practices committed to improving medical care for a range of health problems, offer ideal settings for these trials, especially pragmatic clinical trials. However, many researchers are not familiar with working with PBRNs.

methodsExperts in practice-based research identified solutions to challenges that researchers and PBRN personnel experience when collaborating on clinical trials in PBRNs. These were organized as frequently asked questions in a draft document presented at a 2013 Agency for Health care Research and Quality PBRN conference workshop, revised based on participant feedback, then shared with additional experts from the DARTNet Institute, Clinical Translational Science Award PBRN, and North American Primary Care Research Group PBRN workgroups for further input and modification.

resultsThe "Toolkit for Developing and Conducting Multi-site Clinical Trials in Practice-Based Research Networks" offers guidance in the areas of recruiting and engaging practices, budgeting, project management, and communication, as well as templates and examples of tools important in developing and conducting clinical trials.

conclusionEnsuring the successful development and conduct of clinical trials in PBRNs requires a highly collaborative approach between academic research and PBRN teams.

Indexed as

Clinical Trials as TopicMulticenter Studies as TopicBudgetsCommunicationPersonnel SelectionClinical Trials as TopicPractice-based Research

Identifiers

PMID25381071
PMCPMC4297606

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.