Trial reportTechniques in coloproctology2015
A randomized pilot study on single-port versus conventional laparoscopic rectal surgery: effects on postoperative pain and the stress response to surgery.
Trial report in Techniques in coloproctology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 7 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- A systematic review on biomarkers implemented to measure surgical stress response in patients undergoing colorectal surgery.International journal of colorectal disease · 2025Pooled it
- Single incision laparoscopy versus conventional multiport laparoscopy for colorectal surgery: a systematic review and meta-analysis.Annals of the Royal College of Surgeons of England · 2023Pooled it
- Single-incision versus conventional multiport laparoscopic surgery for colorectal cancer: a meta-analysis of randomized controlled trials and propensity-score matched studies.International journal of colorectal disease · 2021Pooled it
- Single-Incision vs. Conventional Laparoscopic Surgery for Colorectal Cancer: An Update of a Systematic Review and Meta-Analysis.Frontiers in surgery · 2021Pooled it
- European association for endoscopic surgery (EAES) consensus statement on single-incision endoscopic surgery.Surgical endoscopy · 2019Guideline
- Systematic review of single-incision versus conventional multiport laparoscopic surgery for sigmoid colon and rectal cancer.World journal of surgical oncology · 2018Pooled it
- Short-Term Outcomes of Single-Incision Versus Conventional Laparoscopic Surgery for Colorectal Diseases: Meta-Analysis of Randomized and Prospective Evidence.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Pooled it
- Protective effect of dexmedetomidine infusion combined with epidural blockade on postoperative complications after surgery: A prospective randomized controlled clinical trial.The Journal of international medical research · 2020Trial
- C-reactive protein in predicting major postoperative complications are there differences in open and minimally invasive colorectal surgery? Substudy from a randomized clinical trial.Surgical endoscopy · 2018Trial
- Carbon dioxide laparoscopic technology: research hotspots and innovations in pneumoperitoneum detection.Medical gas research · 2026Review
- Short-term outcomes of single-port versus multi-port robotic surgery for colorectal cancer: a propensity score-matched analysis.Surgical endoscopy · 2026Article
- Efficacy and safety of reduced-port laparoscopic surgery versus conventional laparoscopic surgery for colorectal cancer.BMC cancer · 2025Article
- Comparative study of single-port single-channel and single-port multi-channel adrenalectomy in various maximum tumor diameters.BMC surgery · 2025Article
- Evaluating the safety and efficacy of SILS and SILS+1 port laparoscopic surgery for colorectal resection: a systematic review with meta-analysis and trial sequential analysis of RCTs.Frontiers in oncology · 2025Review
- The efficacy and safety of single-incision plus one-port laparoscopic surgeryGland surgery · 2024Article
- Is single incision laparoscopic surgery (SILS) for gastric gastrointestinal stromal tumor (GIST) dependent on the location of the tumor?BMC surgery · 2023Article
- Single-incision versus conventional laparoscopic surgery for rectal cancer: a meta-analysis of clinical and pathological outcomes.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2022Review
- Article
- Single-operator-conducted natural orifice specimen extraction surgery (NOSES) for sigmoid colon cancer.Gastroenterology report · 2022Article
- Comparison of clinical efficacy of single-incision and traditional laparoscopic surgery for colorectal cancer: A meta-analysis of randomized controlled trials and propensity-score matched studies.Frontiers in oncology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPotential benefits of single-port laparoscopic surgery may include improved cosmetic results, less postoperative pain, surgical trauma and faster recovery. Results of randomized prospective studies with a focus on single-port rectal surgery have not yet been presented. The aim of the present study was to compare single-port and conventional laparoscopic surgery for rectal cancer in terms of short-term outcomes including postoperative pain and trauma-induced changes in certain bioactive substances.
methodsPatients with non-metastasized rectal cancer were prospectively randomized to single-port (n = 20) or conventional laparoscopic rectal surgery (n = 20). Postoperative pain was assessed at rest, at coughing and during mobilization, with a numeric pain ranking score and was recorded at 6 h after the operation and subsequently every morning daily for 4 days. Levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tissue inhibitor of metalloproteinases-1 (TIMP-1) were determined. Blood samples were collected preoperatively (baseline), and 6, 24, 48, 72 and 96 h after skin incision.
resultsPain scores were significantly reduced in the single-port group on postoperative days 2, 3 and 4 during coughing and mobilization. In addition, the patients in the single-port group suffered significantly less pain at rest at 6 h after surgery and on postoperative days 1, 3 and 4. The levels of the three markers increased significantly after surgery. The increase was similar between groups for plasma IL-6 and TIMP-1 at all time points, while the CRP levels were significantly lower in the single-port group at 6 (p < 0.001) and 24 h (p < 0.05) after skin incision. Abdominal incisions lengths were significantly shorter in the single-port group (p = 0.001). There was no significant difference between groups in operating time and blood loss, morbidity or mortality rate. The short-term oncological outcome in the two groups was similar.
conclusionsSingle-port rectal surgery may reduce postoperative pain. Although CRP levels were lower at some time points, results of the present randomized, pilot study suggest that the trauma-induced inflammatory response of single-port operations may be similar to the trauma-induced inflammatory response of conventional laparoscopic surgery.
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