Trial reportAge (Dordrecht, Netherlands)2014
Acute exercise increases resistance to oxidative stress in young but not older adults.
Trial report in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Effects of acute, subacute, and chronic exercise on plasma s-Klotho levels: a systematic review and meta-analysis.Journal of physiology and biochemistry · 2026Pooled it
- Comparison of the acute effects of traditional versus high velocity resistance training on metabolic, cardiovascular, and psychophysiological responses in elderly hypertensive women.Clinical interventions in aging · 2018Trial
- Sulforaphane improves exercise-induced NRF2 signaling in older adults: an in vivo-ex vivo approach.GeroScience · 2026Article
- The Impact of Exercise on Redox Equilibrium in Cardiovascular Diseases.Journal of clinical medicine · 2022Review
- Well-Trained Elders Have Antioxidant Responses and an Equal Magnitude of EIMD as Young Adults.International journal of environmental research and public health · 2022Article
- Exercise as an Aging Mimetic: A New Perspective on the Mechanisms Behind Exercise as Preventive Medicine Against Age-Related Chronic Disease.Frontiers in physiology · 2022Article
- Exercise-Induced Regulation of Redox Status in Cardiovascular Diseases: The Role of Exercise Training and Detraining.Antioxidants (Basel, Switzerland) · 2019Review
- Changes in oxidative stress, inflammation and muscle damage markers following eccentric versus concentric cycling in older adults.European journal of applied physiology · 2019Article
- Changes in oxidative stress levels during two weeks of smoking cessation treatment and their association with nutritional characteristics in Japanese smokers.Experimental and therapeutic medicine · 2019Article
- Hemorrhage simulated by lower body negative pressure provokes an oxidative stress response in healthy young adults.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction.Frontiers in physiology · 2019Review
- Isoprostanes as markers for muscle aging in older athletes.Biochimie open · 2018Article
- Opposing Effects of Oxygen Regulation on Kallistatin Expression: Kallistatin as a Novel Mediator of Oxygen-Induced HIF-1-eNOS-NO Pathway.Oxidative medicine and cellular longevity · 2017Review
- Aerobic exercise increases resistance to oxidative stress in sedentary older middle-aged adults. A pilot study.Age (Dordrecht, Netherlands) · 2016Article
- Effects of prior exercise on glycemic responses following carbohydrate inges on in individuals with type 2 diabetes.Journal of clinical and translational research · 2015Article
- Relationship Between Aerobic Capacity With Oxidative Stress and Inflammation Biomarkers in the Blood of Older Mexican Urban-Dwelling Population.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A single bout of acute exercise increases oxidative stress and stimulates a transient increase in antioxidant enzymes. We asked whether this response would induce protection from a subsequent oxidative challenge, different from that of exercise, and whether the effects were affected by aging. We compared young (20 ± 1 years, n = 8) and older (58 ± 6 years, n = 9) healthy men and women. Resistance to oxidative stress was measured by the F2-isoprostane response to forearm ischemia/reperfusion (I/R) trial. Each participant underwent the I/R trial twice, in random order; once after performing 45 min of cycling on the preceding day (IRX) and a control trial without any physical activity (IRC). Baseline F2-isoprostane levels were significantly lower at IRX compared to IRC (P < 0.05) and not different between groups. F2-isoprostane response to IRX was significantly lower compared to IRC in young (P < 0.05) but not different in the older group. Superoxide dismutase activity in response to acute exercise was significantly higher in young compared to older adults (P < 0.05). These data suggest that signal transduction of acute exercise may be impaired with aging. Repeated bouts of transient reactive oxygen species production as seen with regular exercise may be needed to increase resistance to oxidative stress in older individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.