ArticleThe American journal of pathology1989
Gelsolin modulation in epithelial and stromal cells of mammary carcinoma.
Article in The American journal of pathology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 75 citations in OpenAlex.
- Two-Dimensional Polyacrylamide Gel Electrophoresis Coupled with Nanoliquid Chromatography-Tandem Mass Spectrometry-Based Identification of Differentially Expressed Proteins and Tumorigenic Pathways in the MCF7 Breast Cancer Cell Line Transfected for Jumping Translocation Breakpoint Protein Overexpression.International journal of molecular sciences · 2023Article
- Cellular transcriptomics: gelsolin negatively regulates the expression of apoptosis-associated genes and inhibits apoptosis in hepatocarcinoma cells.International journal of clinical and experimental pathology · 2015Article
- Gelsolin gene expression is upregulated in damaged rat and human livers within non-parenchymal cells and not in hepatocytes.Histochemistry and cell biology · 2003Article
- The optical stretcher: a novel laser tool to micromanipulate cells.Biophysical journal · 2001Article
- Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength.The Journal of cell biology · 2000Article
- Caspase-mediated cleavage of cytoskeletal actin plays a positive role in the process of morphological apoptosis.Oncogene · 1999Article
- Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase.Oncogene · 1999Article
- Polarized distribution of actin isoforms in gastric parietal cells.Molecular biology of the cell · 1995Article
- Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets.Molecular biology of the cell · 1994Article
- Distribution of gelsolin in mouse ovary.Cell and tissue research · 1994Article
- Actin structural proteins in cell motility.Cancer metastasis reviews · 1992Review
- Are the conserved sequences in segment 1 of gelsolin important for binding actin?The Journal of cell biology · 1992Article
- Expression of IGF-I and IGF-II mRNA in breast tissue.Breast cancer research and treatment · 1992Article
- Helium-neon laser treatment transforms fibroblasts into myofibroblasts.The American journal of pathology · 1990Article
- Comparative two-dimensional gel analysis and microsequencing identifies gelsolin as one of the most prominent downregulated markers of transformed human fibroblast and epithelial cells.The Journal of cell biology · 1990Article
- Colonic pericryptal fibroblasts. Differentiation pattern in embryogenesis and phenotypic modulation in epithelial proliferative lesions.Virchows Archiv. A, Pathological anatomy and histopathology · 1989Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gelsolin, a Ca2+-sensitive protein present in many mammalian cells, regulates actin filament length by multiple mechanisms. In tumor cells, increased amounts of F-actin without change in its total amount have been observed, suggesting a modification in the organisation of this protein. The authors have localized gelsolin, total actin, alpha-smooth muscle actin, and prekeratin in frozen sections of normal human breast and infiltrating duct carcinomas by immunohistochemistry. A positive staining for gelsolin was observed in normal epithelial and myoepithelial cells but not in stromal fibroblasts. In contrast, no staining for gelsolin was detectable in carcinomatous cells, with the exception of remaining myoepithelial cells; myofibroblasts of the stromal reaction displayed an intense positive reaction. The absence of gelsolin staining in the epithelial cells of breast carcinoma may reflect their dedifferentiation or proliferative and invasive activities. The appearance of gelsolin in stromal cells raises the question as to what is its function in this situation. The immunohistochemical detection of gelsolin may be a useful adjunct to the study of mammary gland epithelium malignant transformation.
Indexed as
Identifiers
2538057PMC1879521W165630538What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.