SynthesisPloS one2014
The value of diffusion tensor imaging in differentiating high-grade gliomas from brain metastases: a systematic review and meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diffusion-Weighted Imaging and Diffusion Tensor Imaging for Differentiating High-Grade Glioma from Solitary Brain Metastasis: A Systematic Review and Meta-Analysis.AJNR. American journal of neuroradiology · 2018Pooled it
- Role of Diffusion Tensor Imaging in Grading of Brain Tumors and Assessment of White Matter Tract Invasion.Asian journal of neurosurgery · 2026Article
- Imaging in Neuro-oncology.Seminars in neurology · 2025Review
- Longitudinal Cerebral Structural, Microstructural, and Functional Alterations After Brain Tumor Surgery for Early Detection of Recurrent Tumors.Biomedicines · 2025Article
- Utilizing Diffusion Tensor Imaging to Differentiate High-Grade Gliomas and Solitary Brain Metastases.Asian journal of neurosurgery · 2025Article
- Advanced diffusion MRI provides evidence for altered axonal microstructure and gradual peritumoral infiltration in GBM in comparison to brain metastases.Clinical neuroradiology · 2024Article
- Review
- Article
- DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy Subjects.Current oncology (Toronto, Ont.) · 2022Article
- Diffusion Microstructure Imaging to Analyze Perilesional T2 Signal Changes in Brain Metastases and Glioblastomas.Cancers · 2022Article
- Feasibility of generalised diffusion kurtosis imaging approach for brain glioma grading.Neuroradiology · 2021Article
- MRI biomarkers in neuro-oncology.Nature reviews. Neurology · 2021Review
- Review
- Role of Diffusion Tensor Imaging Parameters in the Characterization and Differentiation of Infiltrating and Non-Infiltrating Spinal Cord Tumors : Preliminary Study.Clinical neuroradiology · 2020Article
- A Mistaken Diagnosis of Secondary Glioblastoma as Parasitosis.Frontiers in neurology · 2019Article
- Multimodal MRI characteristics of the glioblastoma infiltration beyond contrast enhancement.Therapeutic advances in neurological disorders · 2019Article
- Current Applications of Diffusion Tensor Imaging and Tractography in Intracranial Tumor Resection.Frontiers in oncology · 2019Review
- T-Cell Densities in Brain Metastases Are Associated with Patient Survival Times and Diffusion Tensor MRI Changes.Cancer research · 2018Article
- Histogram analysis of DTI-derived indices reveals pontocerebellar degeneration and its progression in SCA2.PloS one · 2018Article
- Mechanisms and Therapy for Cancer Metastasis to the Brain.Frontiers in oncology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDifferentiation of high-grade gliomas and solitary brain metastases is an important clinical issue because the treatment strategies differ greatly. Our study aimed to investigate the potential value of diffusion tensor imaging (DTI) in differentiating high-grade gliomas from brain metastases using a meta-analytic approach. MATERIALS AND
methodsWe searched Pubmed, Embase and the Cochrane Library for relevant articles published in English. Studies that both investigated high-grade gliomas and brain metastases using DTI were included. Random effect model was used to compare fractional anisotropy (FA) and mean diffusivity (MD) values in the two tumor entities.
resultsNine studies were included into the meta-analysis. In the peritumoral region, compared with brain metastases, high-grade gliomas had a significant increase of FA (SMD = 0.47; 95% CI, 0.22-0.71; P<0.01) and a significant decrease of MD (SMD = -1.49; 95% CI, -1.91 to -1.06; P<0.01). However, in the intratumoral area, no significant change in FA (SMD = 0.16; 95% CI, -0.49 to 0.82; P = 0.73) or MD (SMD = 0.34; 95% CI, -0.91 to 1.60; P = 0.59) was detected between gliomas and metastases.
conclusionsHigh-grade gliomas may be distinguished from brain metastases by comparing the peritumoral FA and MD values. DTI appears to be a promising tool in diagnosing solitary intracranial lesions.
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