ArticlePloS one2014
Differential antigen expression profile predicts immunoreactive subset of advanced ovarian cancers.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Inflammation and immunity in ovarian cancer.EJC supplements : EJC : official journal of EORTC, European Organization for Research and Treatment of Cancer ... [et al.] · 2020Article
- Interferon signaling in ascites-associated macrophages is linked to a favorable clinical outcome in a subgroup of ovarian carcinoma patients.BMC genomics · 2017Article
- Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review.Frontiers in immunology · 2017Review
- Utility of the dual-specificity protein kinase TTK as a therapeutic target for intrahepatic spread of liver cancer.Scientific reports · 2016Article
- Cancer-Testis Gene Expression in Hepatocellular Carcinoma: Identification of Prognostic Markers and Potential Targets for Immunotherapy.Technology in cancer research & treatmentArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The presence and composition of lymphocytes characterizing an immune response has been connected to prognosis in advanced ovarian cancer. Our aim is to establish novel associations between prognosis and the expression of immune-related genes through a focused screen utilizing publicly available high-throughput assays. We consider transcriptome profiles from n=1137 advanced ovarian cancer patients observed in four separate studies divided into discovery/validation sets (n=503/n=634). We focus on a subset of lymphocyte markers, antigen presentation and processing genes, T cell receptor associated co-stimulatory/repressor genes and cancer testis (CT) antigens. We modeled differential expression and co-expression using these subsets and tested for association with overall survival. Fifteen of 64 immune-related genes are associated with survival of which 5 are reproduced in the validation set. The expression of these genes defines an immunoreactive (IR) subgroup of patients with a favorable prognosis. Phenotypic characterization of the immune compartment signal includes upregulation of markers of CD8+ T-cell activation in these patients. Using multivariate model building, we find that the expression of 6 CT antigens can predict IR status in the discovery and validation sets. These analyses confirm that a genomic approach can reproducibly detect lymphocyte signals in tumor tissue suggesting a novel way to study the tumor microenvironment. Our search has identified new candidate prognostic markers associated with immune components and uncovered preliminary evidence of prognostic subgroups associated with different immune mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.