ArticleLangmuir : the ACS journal of surfaces and colloids2014
Mimicking the hierarchical functions of dentin collagen cross-links with plant derived phenols and phenolic acids.
Article in Langmuir : the ACS journal of surfaces and colloids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 78 citations in OpenAlex.
- Accessing Polyphenols Effect on Bond Strength and Dentin Enzymatic Degradation.Clinical and experimental dental research · 2026Article
- Gallic acid as a biointeractive dentin conditioning agent for universal adhesives: bond strength, iron retention, and surface characterization following ferric sulfate hemostatic contamination.Clinical oral investigations · 2026Article
- Supramolecular strategy for compartment pathogen clearance and immuno-metabolic homeostasis to treat periodontitis.Nature communications · 2026Article
- Advanced biomechanics and stability of the resin-dentin complex via modular A- and B-type proanthocyanidins.Biomaterials · 2026Article
- The contribution of different types of polyphenols to bonding performance by enhancing the stabilization of the hybrid layer.Clinical oral investigations · 2026Article
- A Bioinspired Approach to Mechanically Reinforce Collagen-Rich Tissues Using Modularly Defined Stilbenoids.Biopolymers · 2026Article
- Structure-activity relationships of A-and B-type proanthocyanidins in long-term dentin biomodification and biocompatibility.Journal of dentistry · 2025Article
- A dual action approach of B-type proanthocyanidins for silencing enzymatic activity and sealing natural caries-affected dentin-resin interfaces.Journal of dentistry · 2025Article
- Regulatory potency of oligomeric proanthocyanidins (PACs) on extrafibrillar and intrafibrillar collagen mineralization.Journal of applied polymer science · 2025Article
- Prodelphinidins enhance dentin matrix properties and promote adhesion to methacrylate resin.Dental materials : official publication of the Academy of Dental Materials · 2024Article
- Modulatory role of terminal monomeric flavan-3-ol units in the viscoelasticity of dentin.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- The Potential Uses of Baobab Tree's Medicinal Effects in Dentistry: A Literature Review.Cureus · 2023Review
- Development of Proanthocyanidin-Loaded Mesoporous Silica Nanoparticles for Improving Dental Adhesion.Molecular pharmaceutics · 2022Article
- B-type Proanthocyanidins with Dentin Biomodification Activity from Cocoa (Journal of agricultural and food chemistry · 2022Article
- Proanthocyanidin Tetramers and Pentamers fromJournal of natural products · 2022Article
- Paradoxical effects of galloyl motifs in the interactions of proanthocyanidins with collagen-rich dentin.Journal of biomedical materials research. Part A · 2022Article
- Distinct effects of polyphenols and solvents on dentin collagen crosslinking interactions and biostability.Dental materials : official publication of the Academy of Dental Materials · 2021Article
- Unveiling structure-activity relationships of proanthocyanidins with dentin collagen.Dental materials : official publication of the Academy of Dental Materials · 2021Article
- Push Out Bond Strength of a Glass Fibre Post to Root Dentine Pretreated with Proanthocyanidin and Phytosphingosine - An In Vitro Study.European endodontic journal · 2021Article
- A dynamic mechanical method to assess bulk viscoelastic behavior of the dentin extracellular matrix.Dental materials : official publication of the Academy of Dental Materials · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Proanthocyanidins (PACs) are secondary plant metabolites that mediate nonenzymatic collagen cross-linking and enhance the properties of collagen based tissue, such as dentin. The extent and nature of cross-linking is influenced by the composition and specific chemical structure of the bioactive compounds present in certain PAC-rich extracts. This study investigated the effect of the molecular weight and stereochemistry of polyphenol compounds on two important properties of dentin, biomechanics, and biostability. For that, purified phenols, a phenolic acid, and some of its derivatives were selected: PAC dimers (A1, A2, B1, and B2) and a trimer (C1), gallic acid (Ga), its esters methyl-gallate (MGa) and propyl-gallate (PGa), and a pentagalloyl ester of glucose (PGG). Synergism was assessed by combining the most active PAC and gallic acid derivative. Mechanical properties of dentin organic matrix were determined by the modulus of elasticity obtained in a flexural test. Biostability was evaluated by the resistance to collagenase degradation. PACs significantly enhanced dentin mechanical properties and decreased collagen digestion. Among the gallic acid derivatives, only PGG had a significant enhancing effect. The lack of observed C1:PGG synergy indicates that both compounds have similar mechanisms of interaction with the dentin matrix. These findings reveal that the molecular weight of polyphenols have a determinant effect on their interaction with type I collagen and modulates the mechanism of cross-linking at the molecular, intermolecular, and inter-microfibrillar levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.