ArticleProceedings of the National Academy of Sciences of the United States of America1989
Cell cultures of neuroblasts from rat olfactory epithelium that show odorant responses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 47 citations in OpenAlex.
- Nonintegrin laminin receptor precursor protein is expressed on olfactory stem and progenitor cells.The Journal of comparative neurology · 2007Article
- Reconstructing smell.Molecular neurobiology · 2000Review
- Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres.Nature medicine · 1995Article
- Long-term culture and functional characterization of follicular cells from adult normal human thyroids.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Olfactory organ culture in vivo and in vitro.Cytotechnology · 1993Review
- Regulation of olfactory neuron gene expression.Cytotechnology · 1993Review
- Continuous culture of neuronal cells from adult human olfactory epithelium.Journal of molecular neuroscience : MN · 1992Article
- Novel genes for potential ligand-binding proteins in subregions of the olfactory mucosa.The EMBO journal · 1991Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have developed procedures that permit isolation and propagation of clonal cell cultures from the olfactory epithelium of the 5- to 7-day-old rat that appear to represent the neuroblasts that repopulate the sensory neurons in the olfactory epithelium throughout life. The cell lines we report here synthesize neuron-specific enolase, which is a neuron marker, 43-kDa growth-associated protein, a protein associated with neuronal growth cones, and carnosine, a possible olfactory neurotransmitter. In two of the cell lines we have found dose-dependent cAMP accumulation following exposure to submicromolar concentrations of chemical odorants in the medium. These two cell lines show different patterns of odorant specificity when tested against a panel of six chemicals commonly used as test odorants. We anticipate that these and similarly derived cell lines will prove valuable in studying aspects of neurogenesis and olfaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.