ArticlePloS one2014
Anatomic distribution of nerves and microvascular density in the human anterior vaginal wall: prospective study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Micro-computed tomography to visualize preserved vascular architecture in decellularized human vaginal tissue: explorative study.Scientific reports · 2025Article
- Somatic and autonomic nerve density of the urethra, periurethral tissue, and anterior vaginal wall: an immunohistochemical study in adult female cadavers.International urogynecology journal · 2023Article
- Morphological changes in the anterior vaginal wall caused by aging: a scanning electron microscopy study.International urogynecology journal · 2023Article
- Efficacy and Safety of Platelet-Rich Plasma Injections for the Treatment of Female Sexual Dysfunction and Stress Urinary Incontinence: A Systematic Review.Biomedicines · 2023Review
- Male esthetic genital surgery: recommendations and gaps to be filled.International journal of impotence research · 2022Article
- Characteristics of Non-Ablative Resurfacing of Soft Tissues by Repetitive Er:YAG Laser Pulse Irradiation.Lasers in surgery and medicine · 2021Article
- G-spot: Fact or Fiction?: A Systematic Review.Sexual medicine · 2021Review
- Materials Selection for the Injection into Vaginal Wall for Treatment of Vaginal Atrophy.Aesthetic plastic surgery · 2021Review
- Search for the G spot: microvessel and nerve mapping of the paraurethral anterior vaginal wall.International urogynecology journal · 2020Article
- The Effect of Different Surgical Methods on Female and Male Sexual Activity and Marital Quality in Patients With Early-Stage Cervical Cancer.Sexual medicine · 2020Article
- Platelet-rich plasma administration to the lower anterior vaginal wall to improve female sexuality satisfaction.Turkish journal of obstetrics and gynecology · 2019Article
- Women self-reported G-spot existence and relation with sexual function and genital perception.Turkish journal of obstetrics and gynecology · 2018Article
- Estrogen Replacement Regulates Vaginal Innervations in Ovariectomized Adult Virgin Rats: A Histological Study.BioMed research international · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe presence of the G-spot (an assumed erotic sensitive area in the anterior wall of the vagina) remains controversial. We explored the histomorphological basis of the G-spot.
methodsBiopsies were drawn from a 12 o'clock direction in the distal- and proximal-third areas of the anterior vagina of 32 Chinese subjects. The total number of protein gene product 9.5-immunoreactive nerves and smooth muscle actin-immunoreactive blood vessels in each specimen was quantified using the avidin-biotin-peroxidase assay.
resultsVaginal innervation was observed in the lamina propria and muscle layer of the anterior vaginal wall. The distal-third of the anterior vaginal wall had significantly richer small-nerve-fiber innervation in the lamina propria than the proximal-third (p = 0.000) and in the vaginal muscle layer (p = 0.006). There were abundant microvessels in the lamina propria and muscle layer, but no small vessels in the lamina propria and few in the muscle layer. Significant differences were noted in the number of microvessels when comparing the distal- with proximal-third parts in the lamina propria (p = 0.046) and muscle layer (p = 0.002).
conclusionsSignificantly increased density of nerves and microvessels in the distal-third of the anterior vaginal wall could be the histomorphological basis of the G-spot. Distal anterior vaginal repair could disrupt the normal anatomy, neurovascular supply and function of the G-spot, and cause sexual dysfunction.
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